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Noradrenergic arousal after encoding reverses the course of systems consolidation in humans
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Noradrenergic arousal after encoding reverses the course of systems consolidation in humans
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Journal Article
Noradrenergic arousal after encoding reverses the course of systems consolidation in humans
2021
Overview
It is commonly assumed that episodic memories undergo a time-dependent systems consolidation process, during which hippocampus-dependent memories eventually become reliant on neocortical areas. Here we show that systems consolidation dynamics can be experimentally manipulated and even reversed. We combined a single pharmacological elevation of post-encoding noradrenergic activity through the α
2
-adrenoceptor antagonist yohimbine with fMRI scanning both during encoding and recognition testing either 1 or 28 days later. We show that yohimbine administration, in contrast to placebo, leads to a time-dependent increase in hippocampal activity and multivariate encoding-retrieval pattern similarity, an indicator of episodic reinstatement, between 1 and 28 days. This is accompanied by a time-dependent decrease in neocortical activity. Behaviorally, these neural changes are linked to a reduced memory decline over time after yohimbine intake. These findings indicate that noradrenergic activity shortly after encoding may alter and even reverse systems consolidation in humans, thus maintaining vividness of memories over time.
Memories are assumed to undergo a time-dependent systems consolidation, during which hippocampal contributions to memory decrease while neocortical contributions increase. Here, the authors show that noradrenergic arousal after encoding may reverse this course of systems consolidation in humans
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ Adult
/ Arousal
/ Female
/ Functional magnetic resonance imaging
/ Humanities and Social Sciences
/ Humans
/ Male
/ Memory Consolidation - drug effects
/ Memory, Long-Term - drug effects
/ Memory, Long-Term - physiology
/ Norepinephrine - pharmacology
/ Placebos
/ Recognition, Psychology - drug effects
/ Recognition, Psychology - physiology
/ Science
