Asset Details

MbrlCatalogueTitleDetail

Do you wish to reserve the book?

Structure of the CCR5 Chemokine Receptor—HIV Entry Inhibitor Maraviroc Complex

by Cherezov, Vadim , Tan, Qiuxiang , Kufareva, Irina , Fenalti, Gustavo , Han, Gye Won , Li, Jing , Liu, Hong , Zhu, Ya , Yang, Huaiyu , Chen, Zhuxi , Li, Tingting , Zhao, Qiang , Stevens, Raymond C. , Ma, Limin , Zhang, Wenru , Wu, Beili , Li, Jian , Xie, Xin , Jiang, Hualiang

in Binding Sites / Carbon / CCR5 receptor / Chemokines / Crystal structure / CXCR4 receptor / Cyclohexanes - chemistry / Cyclohexanes - pharmacology / Grants / HIV / HIV 1 / HIV Envelope Protein gp120 - metabolism / HIV Fusion Inhibitors - chemistry / HIV Fusion Inhibitors - pharmacology / HIV infections / HIV-1 - drug effects / HIV-1 - physiology / Human immunodeficiency virus / Human immunodeficiency virus 1 / Humans / Infections / Ligands / Maraviroc / Neurons / Protein Conformation / Receptors / Receptors, CCR5 - chemistry / Receptors, CCR5 - metabolism / Receptors, CXCR4 - chemistry / Triazoles - chemistry / Triazoles - pharmacology / Viral morphology / Virus Internalization - drug effects / Viruses

2013

Yes Please

Hey, we have placed the reservation for you!

By the way, why not check out events that you can attend while you pick your title.

Oops! Something went wrong.

Looks like we were not able to place the reservation. Kindly try again later.

Are you sure you want to remove the book from the shelf?

Structure of the CCR5 Chemokine Receptor—HIV Entry Inhibitor Maraviroc Complex

2013

Confirm

Do you wish to request the book?

Structure of the CCR5 Chemokine Receptor—HIV Entry Inhibitor Maraviroc Complex

2013

Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy

How would you like to get it?

Submit

We have requested the book for you!

Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.

Oops! Something went wrong.

Looks like we were not able to place your request. Kindly try again later.

Journal Article

Structure of the CCR5 Chemokine Receptor—HIV Entry Inhibitor Maraviroc Complex

Cherezov, Vadim,

Tan, Qiuxiang,

Kufareva, Irina,

Fenalti, Gustavo,

Han, Gye Won,

Li, Jing,

Liu, Hong,

Zhu, Ya,

Yang, Huaiyu,

Chen, Zhuxi,

Li, Tingting,

Zhao, Qiang,

Stevens, Raymond C.,

Ma, Limin,

Zhang, Wenru,

Wu, Beili,

Li, Jian,

Xie, Xin,

Jiang, Hualiang

2013

Overview

The CCR5 chemokine receptor acts as a co-receptor for HIV-1 viral entry. Here we report the 2.7 angstrom-resolution crystal structure of human CCR5 bound to the marketed HIV drug maraviroc. The structure reveals a ligand-binding site that is distinct from the proposed major recognition sites for chemokines and the viral glycoprotein gp120, providing insights into the mechanism of allosteric inhibition of chemokine signaling and viral entry. A comparison between CCR5 and CXCR4 crystal structures, along with models of co-receptor—gp120-V3 complexes, suggests that different charge distributions and steric hindrances caused by residue substitutions may be major determinants of HIV-1 co-receptor selectivity. These high-resolution insights into CCR5 can enable structure-based drug discovery for the treatment of HIV-1 infection.

Share this book

Add to My Shelf

Publisher

American Association for the Advancement of Science,The American Association for the Advancement of Science,AAAS

Subject

/ Carbon

/ Cyclohexanes - chemistry