Asset Details
Do you wish to reserve the book?
The structure and function of Iristatin, a novel immunosuppressive tick salivary cystatin
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
The structure and function of Iristatin, a novel immunosuppressive tick salivary cystatin
Do you wish to request the book?
The structure and function of Iristatin, a novel immunosuppressive tick salivary cystatin
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
The structure and function of Iristatin, a novel immunosuppressive tick salivary cystatin
2019
Overview
To successfully feed, ticks inject pharmacoactive molecules into the vertebrate host including cystatin cysteine protease inhibitors. However, the molecular and cellular events modulated by tick saliva remain largely unknown. Here, we describe and characterize a novel immunomodulatory cystatin, Iristatin, which is upregulated in the salivary glands of feeding
Ixodes ricinus
ticks. We present the crystal structure of Iristatin at 1.76 Å resolution. Purified recombinant Iristatin inhibited the proteolytic activity of cathepsins L and C and diminished IL-2, IL-4, IL-9, and IFN-γ production by different T-cell populations, IL-6 and IL-9 production by mast cells, and nitric oxide production by macrophages. Furthermore, Iristatin inhibited OVA antigen-induced CD4
+
T-cell proliferation and leukocyte recruitment in vivo and in vitro. Our results indicate that Iristatin affects wide range of anti-tick immune responses in the vertebrate host and may be exploitable as an immunotherapeutic.
Publisher
Springer International Publishing,Springer Nature B.V
Subject
/ Animals
/ Antigens
/ Arthropod Proteins - chemistry
/ Arthropod Proteins - genetics
/ Arthropod Proteins - pharmacology
/ Biomedical and Life Sciences
/ cysteine proteinase inhibitors
/ Enzymes
/ Epoxy Compounds - metabolism
/ Female
/ Immunosuppressive Agents - chemistry
/ Immunosuppressive Agents - metabolism
/ Immunosuppressive Agents - pharmacology
/ Original
/ Saliva
/ Salivary Cystatins - chemistry
/ Salivary Cystatins - genetics
/ Salivary Cystatins - pharmacology
/ Sequence Homology, Amino Acid
/ Structure-function relationships
/ T-Lymphocytes - drug effects
/ Ticks
