Journal Article

Supramolecular Nano‐Tracker for Real‐Time Tracking of Drug Release and Efficient Combination Therapy

Chen, Xi, Li, Ru‐Yi, Guo, Dong‐Sheng, Liu, Yang, Dang, Lin, Lu, Yi, Sun, Shao‐Kai, Li, Qiushi, Zheng, Chunxiong, Li, Shujie, Chen, Fang‐Yuan, Zheng, Yadan, Zhang, Zhanzhan

2024

Overview

Real‐time tracking of drug release from nanomedicine in vivo is crucial for optimizing its therapeutic efficacy in clinical settings, particularly in dosage control and determining the optimal therapeutic window. However, most current real‐time tracking systems require a tedious synthesis and purification process. Herein, a supramolecular nano‐tracker (SNT) capable of real‐time tracking of drug release in vivo based on non‐covalent host‐guest interactions is presented. By integrating multiple cavities into a single nanoparticle, SNT achieves co‐loading of drugs and probes while efficiently quenching the photophysical properties of the probe through host‐guest complexation. Moreover, SNT is readily degraded under hypoxic tumor tissues, leading to the simultaneous release of drugs and probes and the fluorescence recovery of probes. With this spatial and temporal consistency in drug loading and fluorescence quenching, as well as drug release and fluorescence recovery, SNT successfully achieves real‐time tracking of drug release in vivo (Pearson r = 0.9166, R2 = 0.8247). Furthermore, the released drugs can synergize effectively with fluorescent probes upon light irradiation, achieving potent chemo‐photodynamic combination therapy in 4T1‐bearing mice with a significantly improved survival rate (33%), providing a potential platform to significantly advance the development of nanomedicine and achieve optimal therapeutic effects in the clinic. Supramolecular nano‐tracker (SNT) is developed for real‐time tracking of drug release in vivo. SNT achieves non‐covalent drugs/probes loading and quenches probe fluorescence under physiological conditions, while releasing cargoes and restoring the probe fluorescence in tumor. Moreover, SNT facilitates chemo‐photodynamic‐based combination therapy upon light irradiation, demonstrating its potential for real‐time tracking of drug release and combination therapy.

• Publisher: John Wiley & Sons, Inc,John Wiley and Sons Inc,Wiley
• Subject: Animals / Combination therapy / Combined Modality Therapy - methods / Disease Models, Animal / Drug delivery systems / Drug Delivery Systems - methods / Drug Liberation / Drugs / Enzymes / host‐guest interaction / Humans / Hypoxia / hypoxic / Mice / Nanomedicine - methods / Nanoparticles / Nanoparticles - chemistry / non‐covalent / Photochemotherapy - methods / real‐time tracking / Tumors