Journal Article

Genotype Score in Addition to Common Risk Factors for Prediction of Type 2 Diabetes

McAteer, Jarred B, Wilson, Peter W.F, Meigs, James B, Manning, Alisa K, Florez, Jose C, Cupples, L. Adrienne, Shrader, Peter, Dupuis, Josée, Sullivan, Lisa M, D'Agostino, Ralph B, Fox, Caroline S

2008

Overview

The authors of this study genotyped single-nucleotide polymorphisms (SNPs) at 18 diabetes-associated loci in participants of the Framingham Offspring Study. A genotype score based on these risk alleles predicted new cases of diabetes but resulted in only a slightly better prediction of risk than knowledge of common risk factors alone. In this study, a genotype score based on 18 diabetes-associated loci predicted new cases of diabetes but resulted in only a slightly better prediction of risk than knowledge of common risk factors alone. Type 2 diabetes mellitus is a major health problem worldwide. 1 Fortunately, its development can be prevented in many instances, 2 and persons at risk can be readily identified with the measurement of a few common risk factors. 3 – 5 Type 2 diabetes is heritable, with a risk for people with familial diabetes as compared with those without familial diabetes that is increased by a factor of 2 to 6. 6 , 7 Recent genetic association studies have provided convincing evidence that several novel loci are associated with the risk of diabetes, 8 – 13 each with a 5 to 37% increase in the relative odds of . . .

• Publisher: Massachusetts Medical Society
• Subject: Adult / Age / Biological and medical sciences / Diabetes / Diabetes Mellitus, Type 2 - genetics / Epidemiology / Family medical history / Female / Follow-Up Studies / Gene Frequency / General aspects / Genetic Predisposition to Disease / Genetics / Genotype / Health risk assessment / Humans / Hypotheses / Logistic Models / Male / Medical sciences / Middle Aged / Phenotype / Polymorphism, Single Nucleotide / Public health. Hygiene / Public health. Hygiene-occupational medicine / Risk Factors