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Alternative splicing of the Anopheles gambiae Dscam gene in diverse Plasmodium falciparum infections
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Alternative splicing of the Anopheles gambiae Dscam gene in diverse Plasmodium falciparum infections
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Journal Article
Alternative splicing of the Anopheles gambiae Dscam gene in diverse Plasmodium falciparum infections
2011
Overview
Background
In insects, including
Anopheles
mosquitoes, Dscam (Down syndrome cell adhesion molecule) appears to be involved in phagocytosis of pathogens, and shows pathogen-specific splice-form expression between divergent pathogen (or parasite) types (e.g. between bacteria and
Plasmodium
or between
Plasmodium berghei
and
Plasmodium falciparum
). Here, data are presented from the first study of
Dscam
expression in response to genetic diversity within a parasite species.
Methods
In independent field and laboratory studies, a measure of Dscam splice-form diversity was compared between mosquitoes fed on blood that was free of
P. falciparum
to mosquitoes exposed to either single or mixed genotype infections of
P. falciparum.
Results
Significant increases in
Anopheles gambiae
Dscam (AgDscam) receptor diversity were observed in parasite-exposed mosquitoes, but only weak evidence that AgDscam diversity rises further upon exposure to mixed genotype parasite infections was found. Finally, a cluster of
AgDscam
exon 4 variants that become especially common during
Plasmodium
invasion was identified.
Conclusions
While the data clearly indicate that AgDscam diversity increases with
P. falciparum
exposure, they do not suggest that AgDscam diversity rises further in response to increased parasite diversity.
Publisher
BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
Subject
/ Animals
/ Bacteria
/ Biomedical and Life Sciences
/ Cell Adhesion Molecules - biosynthesis
/ Cell Adhesion Molecules - genetics
/ Child
/ Cloning
/ DNA
/ Drosophila Proteins - biosynthesis
/ Drosophila Proteins - genetics
/ Female
/ Genomes
/ Genotype
/ Humans
/ Malaria
/ Neural cell adhesion molecule
/ Plasmodium falciparum - genetics
