Asset Details
Do you wish to reserve the book?
An Endothelin-1 Switch Specifies Maxillomandibular Identity
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
An Endothelin-1 Switch Specifies Maxillomandibular Identity
Do you wish to request the book?
An Endothelin-1 Switch Specifies Maxillomandibular Identity
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
An Endothelin-1 Switch Specifies Maxillomandibular Identity
2008
Overview
Articulated jaws are highly conserved structures characteristic of gnathostome evolution. Epithelial-mesenchymal interactions within the first pharyngeal arch (PA1) instruct cephalic neural crest cells (CNCCs) to form the different skeletal elements of the jaws. The endothelin-1 (Edn1)/endothelin receptor type-A (Ednra)→Dlx5/6→Hand2 signaling pathway is necessary for lower jaw formation. Here, we show that the Edn1 signaling is sufficient for the conversion of the maxillary arch to mandibular identity. Constitutive activation of Ednra induced the transformation of upper jaw, maxillary, structures into lower jaw, mandibular, structures with duplicated Meckel's cartilage and dermatocranial jaws constituted by 4 dentary bones. Misexpression of Hand2 in the Ednra domain caused a similar transformation. Skeletal transformations are accompanied by neuromuscular remodeling. Ednra is expressed by most CNCCs, but its constitutive activation affects predominantly PA1. We conclude that after migration CNCCs are not all equivalent, suggesting that their specification occurs in sequential steps. Also, we show that, within PA1, CNCCs are competent to form both mandibular and maxillary structures and that an Edn1 switch is responsible for the choice of either morphogenetic program.
Publisher
National Academy of Sciences,National Acad Sciences
Subject
/ Basic Helix-Loop-Helix Transcription Factors - genetics
/ Basic Helix-Loop-Helix Transcription Factors - metabolism
/ Bones
/ Cells
/ Chimeras
/ Embryology and Organogenesis
/ Embryos
/ Gene Expression Regulation, Developmental
/ Identity
/ Jaw
/ jaws
/ Mandible - anatomy & histology
/ Maxilla
/ Maxilla - anatomy & histology
/ Mice
/ pharynx
/ Receptor, Endothelin A - genetics
