Journal Article

Establishing the effects of mesoporous silica nanoparticle properties on in vivo disposition using imaging-based pharmacokinetics

Wang, Zhihui, Durfee, Paul N., Brinker, C. Jeffrey, Butler, Kimberly S., Adolphi, Natalie L., Coker, Eric N., Dogra, Prashant, Bearer, Elaine L., Cristini, Vittorio, Noureddine, Achraf, Lin, Yu-Shen, Croissant, Jonas G.

2018

Overview

The progress of nanoparticle (NP)-based drug delivery has been hindered by an inability to establish structure-activity relationships in vivo. Here, using stable, monosized, radiolabeled, mesoporous silica nanoparticles (MSNs), we apply an integrated SPECT/CT imaging and mathematical modeling approach to understand the combined effects of MSN size, surface chemistry and routes of administration on biodistribution and clearance kinetics in healthy rats. We show that increased particle size from ~32- to ~142-nm results in a monotonic decrease in systemic bioavailability, irrespective of route of administration, with corresponding accumulation in liver and spleen. Cationic MSNs with surface exposed amines (PEI) have reduced circulation, compared to MSNs of identical size and charge but with shielded amines (QA), due to rapid sequestration into liver and spleen. However, QA show greater total excretion than PEI and their size-matched neutral counterparts (TMS). Overall, we provide important predictive functional correlations to support the rational design of nanomedicines. Nanoparticle applications are limited by insufficient understanding of physiochemical properties on in vivo disposition. Here, the authors explore the influence of size, surface chemistry and administration on the biodisposition of mesoporous silica nanoparticles using image-based pharmacokinetics.

• Publisher: Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
• Subject: 147/143 / 59 / 60 APPLIED LIFE SCIENCES / 639/301/357/354 / 639/705/1046 / 639/925/352/152 / 639/925/352/2733 / 639/925/352/2734 / Amines / Animals / Bioavailability / Computed tomography / Drug delivery / Drug delivery systems / Excretion / Female / Half-Life / Humanities and Social Sciences / imaging techniques and agents / Kinetics / Liver / Mathematical models / multidisciplinary / Nanoparticles / Nanoparticles - chemistry / NANOSCIENCE AND NANOTECHNOLOGY / nanotechnology in cancer / Organic chemistry / Particle Size / Pharmacokinetics / Pharmacology / Porosity / Rats, Inbred F344 / Science / Science (multidisciplinary) / scientific data / Silica / Silicon dioxide / Silicon Dioxide - chemistry / Silicon Dioxide - pharmacokinetics / Single photon emission computed tomography / Spleen / Static Electricity / Structure-activity relationships / Surface chemistry / Tissue Distribution / Tomography, Emission-Computed, Single-Photon / Tomography, X-Ray Computed