Journal Article

A genome-wide association study identifies new susceptibility loci for non-cardia gastric cancer at 3q13.31 and 5p13.1

Zhang, Hanze, Hu, Zhibin, Lin, Dongxin, Ma, Hongxia, Wang, Meilin, Miao, Xiaoping, Chu, Minjie, Hu, Lingmin, Shi, Yongyong, Jiang, Yue, Shen, Hongbing, Jin, Guangfu, Zhang, Zhengdong, Wu, Tangchun, Wu, Chen, Dai, Juncheng, Li, Zhiqiang, Li, Huizhang, Tan, Wen, Dong, Jing, Zhou, Yifeng, Lu, Feng, Chen, Jiaping

2011

Overview

Hongbing Shen, Dongxin Lin, Yongyong Shi and colleagues identify two new susceptibility loci for non-cardia gastric cancer. They also confirm three previously reported risk loci for this gastric cancer subtype. Gastric cancer, including the cardia and non-cardia types, is the second leading cause of cancer-related deaths worldwide. To identify genetic risk variants for non-cardia gastric cancer, we performed a genome-wide association study in 3,279 individuals (1,006 with non-cardia gastric cancer and 2,273 controls) of Chinese descent. We replicated significant associations in an additional 6,897 subjects (3,288 with non-cardia gastric cancer and 3,609 controls). We identified two new susceptibility loci for non-cardia gastric cancer at 5p13.1 (rs13361707 in the region including PTGER4 and PRKAA1 ; odds ratio (OR) = 1.41; P = 7.6 × 10 −29 ) and 3q13.31 (rs9841504 in ZBTB20 ; OR = 0.76; P = 1.7 × 10 −9 ). Imputation analyses also confirmed previously reported associations of rs2294008 and rs2976392 on 8q24, rs4072037 on 1q22 and rs13042395 on 20p13 with non-cardia gastric cancer susceptibility in the Han Chinese population.

• Publisher: Nature Publishing Group US,Nature Publishing Group
• Subject: 631/208/205/2138 / 631/208/727/2000 / 631/67/2324 / 692/699/67/1504/1829 / Adult / Aged / Agriculture / AMP-Activated Protein Kinases - genetics / Animal Genetics and Genomics / Biological and medical sciences / Biomedical and Life Sciences / Biomedicine / Cancer / Cancer Research / Case-Control Studies / Chromosomes, Human, Pair 3 - genetics / Chromosomes, Human, Pair 5 - genetics / Confidence intervals / Development and progression / Disease susceptibility / Female / Fundamental and applied biological sciences. Psychology / Gastroenterology. Liver. Pancreas. Abdomen / Gene Function / Genetic aspects / Genetic Loci / Genetics of eukaryotes. Biological and molecular evolution / Genome-Wide Association Study / Genomes / Health care / Human Genetics / Humans / letter / Male / Medical sciences / Middle Aged / Nerve Tissue Proteins - genetics / Odds Ratio / Pathogenesis / Polymorphism, Single Nucleotide / Public health / R&D / Receptors, Prostaglandin E, EP4 Subtype - genetics / Research & development / Risk factors / Sample size / Single nucleotide polymorphisms / Stomach cancer / Stomach Neoplasms - genetics / Stomach. Duodenum. Small intestine. Colon. Rectum. Anus / Studies / Transcription Factors - genetics / Tumors