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Cerebrospinal fluid biomarkers for Alzheimer's and vascular disease vary by age, gender, and APOE genotype in cognitively normal adults
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Cerebrospinal fluid biomarkers for Alzheimer's and vascular disease vary by age, gender, and APOE genotype in cognitively normal adults
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Journal Article
Cerebrospinal fluid biomarkers for Alzheimer's and vascular disease vary by age, gender, and APOE genotype in cognitively normal adults
2017
Overview
Background
This study sought to evaluate gender and
APOE
genotype-related differences in the concentrations of cerebrospinal fluid (CSF) biomarkers for Alzheimer’s disease (AD) and cerebrovascular injury across the life span of cognitively normal adults.
Methods
CSF amyloid beta
1–42
(Aβ
42
), phospho-tau-181 (p-tau
181
), and total tau were measured in 331 participants who were between the ages of 21 and 100. CSF E-selectin and vascular cell adhesion protein 1 (VCAM1) were measured in 249 participants who were between the ages of 50 and 100.
Results
CSF total tau and p-tau
181
increased with age over the adult life span (
p
< 0.01) with no gender differences in those increases. CSF Aβ
42
concentration varied according to age, gender, and
APOE
genotype (interaction of age × gender × ε4,
p
= 0.047). CSF VCAM1, but not E-selectin, increased with age (
p
< 0.01), but both were elevated in men compared to women (
p
< 0.01).
Conclusions
Female
APOE
-ε4 carriers appear at higher risk for AD after age 50. In contrast, men may experience a relatively higher rate of cerebrovascular injury in middle and early old age.
Publisher
BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
Subject
/ Adults
/ Age
/ Aged
/ Aging
/ Alzheimer Disease - cerebrospinal fluid
/ Alzheimer Disease - genetics
/ Amyloid beta-Peptides - cerebrospinal fluid
/ Analysis
/ Apolipoprotein E4 - genetics
/ Biomarkers - cerebrospinal fluid
/ Biomedical and Life Sciences
/ Dementia
/ Female
/ Fluids
/ Gender
/ Genotype
/ Humans
/ Male
/ Peptide Fragments - cerebrospinal fluid
/ tau Proteins - cerebrospinal fluid
/ Vascular Cell Adhesion Molecule-1 - cerebrospinal fluid
/ Vascular Diseases - cerebrospinal fluid
