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Glutamate exocytosis from astrocytes controls synaptic strength
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Glutamate exocytosis from astrocytes controls synaptic strength
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Journal Article
Glutamate exocytosis from astrocytes controls synaptic strength
2007
Overview
The release of transmitters from glia influences synaptic functions. The modalities and physiological functions of glial release are poorly understood. Here we show that glutamate exocytosis from astrocytes of the rat hippocampal dentate molecular layer enhances synaptic strength at excitatory synapses between perforant path afferents and granule cells. The effect is mediated by ifenprodil-sensitive NMDA ionotropic glutamate receptors and involves an increase of transmitter release at the synapse. Correspondingly, we identify NMDA receptor 2B subunits on the extrasynaptic portion of excitatory nerve terminals. The receptor distribution is spatially related to glutamate-containing synaptic-like microvesicles in the apposed astrocytic processes. This glial regulatory pathway is endogenously activated by neuronal activity–dependent stimulation of purinergic P2Y1 receptors on the astrocytes. Thus, we provide the first combined functional and ultrastructural evidence for a physiological control of synaptic activity via exocytosis of glutamate from astrocytes.
Publisher
Nature Publishing Group US,Nature Publishing Group
Subject
/ Animal Genetics and Genomics
/ Animals
/ Astrocytes - radiation effects
/ Biomedical and Life Sciences
/ Electric Stimulation - methods
/ Excitatory Amino Acid Agonists - pharmacology
/ Excitatory Amino Acid Antagonists - pharmacology
/ Exocytosis - radiation effects
/ Membrane Potentials - drug effects
/ Membrane Potentials - physiology
/ Membrane Potentials - radiation effects
/ Microscopy, Immunoelectron - methods
/ N-Methylaspartate - pharmacology
/ Patch-Clamp Techniques - methods
/ Perforant Pathway - physiology
/ Perforant Pathway - radiation effects
/ Rats
/ Receptors, N-Methyl-D-Aspartate - metabolism
