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Survival analysis of time to cure on multi-drug resistance tuberculosis patients in Amhara region, Ethiopia
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Survival analysis of time to cure on multi-drug resistance tuberculosis patients in Amhara region, Ethiopia
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Journal Article
Survival analysis of time to cure on multi-drug resistance tuberculosis patients in Amhara region, Ethiopia
2019
Overview
Background
Multidrug-resistant tuberculosis (MDR-TB) is caused by bacteria that are resistant to the most effective anti-tuberculosis drug. The MDR-TB is an increasing global problem and the spread of MDR-TB has different recovery time for different patients. Therefore, this study aimed to investigate the recovery time of MDR-TB patients in Amhara region, Ethiopia.
Method
A retrospective study was carried out in seven hospitals having MDR-TB treatment center of Amhara region, Ethiopia from September 2015 to February 2018. An accelerated failure time and parametric shared frailty models were employed.
Results
The study revealed that the recovery time of MDR-TB patients in Amhara region was 21 months. Out of the total MDR-TB patients, 110 (35.4%) censored and 201 (64.6%) cured of MDR-TB. The clustering effect of frailty model was hospitals and the Weibull-gamma shared frailty model was selected among all and hence used for this study. The study showed that extra pulmonary MDR-TB patients had longer recovery time than that of seamier pulmonary MDR-TB patients in Amhara region, Ethiopia. According to this study, male MDR-TB patients, MDR-TB patients with co-morbidity and clinical complication were experiencing longer recovery time than that of the counter groups. This study also showed that MDR-TB patients with poor adherence had longer recovery time than those with good adherence MDR-TB patients.
Conclusion
Among different factors considered in this study, MDR-TB type, clinical complication, adherence, co-morbidities, sex, and smoking status had a significant effect on recovery time of MDR-TB patients in Amhara region, Ethiopia.
In conclusion, the Regional and Federal Government of Ethiopia should take immediate steps to address causes of recovery time of MDR-TB patients in Amhara region through encouraging adherence, early case detection, and proper handling of drug-susceptibility according to WHO guidelines.
Publisher
BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
Subject
Accelerated failure time models
/ Adhesion
/ Bacteria
/ Female
/ Frailty
/ Humans
/ Infectious Disease epidemiology
/ Male
/ Medicine
/ Multidrug resistant organisms
/ Multidrug-resistance tuberculosis
/ Patients
/ Smoking
/ Tuberculosis, Multidrug-Resistant - mortality
/ Tuberculosis, Multidrug-Resistant - therapy
/ Vaccine
