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Neurocutaneous melanosis is not always a benign disease
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Journal Article
Neurocutaneous melanosis is not always a benign disease
2020
Overview
[4] A 22-month-old girl was brought to the outpatient clinic of Mansoura University Children's Hospital, Egypt, with multiple hairy pigmented nevi since birth which progressively increased in size and number over time. [6] In 2014, Küsters-Vandevelde et al. reported a trial of treatment of brain melanoma of neurocutaneous melanosis syndrome using a novel target therapy (MEK162; mitogen- activated protein kinase, MEK inhibitor) against the somatic mutation of NRAS. In 2016, Patel et al. postulated that insulin-like growth factor binding proteins' downregulation enhances the proliferation and viability of neurocutaneous melanosis cells.
Publisher
Wolters Kluwer India Pvt. Ltd,Medknow Publications and Media Pvt. Ltd,Scientific Scholar
