Journal Article

Specification of dorsal telencephalic character by sequential Wnt and FGF signaling

Jessell, Thomas M, Edlund, Thomas, Gunhaga, Lena, Sjödal, My, Marklund, Matthew, Hsieh, Jen-Chih

2003

Overview

Dorsoventral patterning of the telencephalon is established early in forebrain development and underlies many of the regional subdivisions that are critical to the later organization of neural circuits in the cerebral cortex and basal ganglia. Sonic hedgehog (Shh) is involved in the generation of the ventral-most telencephalic cells, but the identity of the extrinsic signal(s) that induce dorsal character in telencephalic cells is not known. Here we show in chick embryos that sequential Wnt and fibroblast growth factor (FGF) signaling specifies cells of dorsal telencephalic character.

• Publisher: Nature Publishing Group US,Nature Publishing Group
• Subject: Aging - genetics / Aging - metabolism / Aging/genetics/metabolism / Analysis / Animal Genetics and Genomics / Animals / Basic Helix-Loop-Helix Transcription Factors / Behavioral Sciences / Biological Techniques / Biomedical and Life Sciences / Biomedicine / Bone Morphogenetic Proteins - physiology / Cell Differentiation / Chick Embryo / Ectoderm - cytology / Ectoderm - physiology / Ectoderm/cytology/physiology / Embryonic Induction - physiology / Epithelium / Eye Proteins / Fibroblast Growth Factors - classification / Fibroblast Growth Factors - genetics / Fibroblast Growth Factors - physiology / Fibroblast Growth Factors/classification/genetics/physiology / Frizzled Receptors / Gene expression / Gene Expression Regulation, Developmental / Homeodomain Proteins - genetics / Homeodomain Proteins - metabolism / Homeodomain Proteins/genetics/metabolism / Immunohistochemistry / In Situ Hybridization - methods / Mice / Nerve Tissue Proteins - genetics / Nerve Tissue Proteins - metabolism / Nerve Tissue Proteins/genetics/metabolism / Neural transmission / Neurobiology / Neurosciences / Organ Culture Techniques / Paired Box Transcription Factors / PAX6 Transcription Factor / Proteins - physiology / Proto-Oncogene Proteins - genetics / Proto-Oncogene Proteins - physiology / Proto-Oncogene Proteins/genetics/physiology / Pyrroles - pharmacology / Receptors, Fibroblast Growth Factor - physiology / Regulation / Repressor Proteins / Signal Transduction - genetics / Signal Transduction - physiology / Signal Transduction/genetics/physiology / Stem Cells - metabolism / Telencephalon / Telencephalon - cytology / Telencephalon - embryology / Telencephalon - metabolism / Telencephalon - physiology / Telencephalon/cytology/embryology/metabolism/physiology / Transcription Factors / Wnt Proteins / Zebrafish Proteins