Journal Article

Uncovering phenotypic heterogeneity through research autopsy in lethal prostate cancer

Chan, Sylvie S.W., Vainauskas, Osvaldas, Attard, Gerhardt

2025

Overview

Tumor heterogeneity in metastatic prostate cancer (mPC) is well established, but comprehensive characterization using routine sampling remains challenging. Autopsy-based research addresses this obstacle by enabling broad tissue collection within individual patients after treatment. In this issue of the JCI, Roudier et al. analyzed samples from a mPC research autopsy cohort, revealing extensive inter- and intratumor heterogeneity across patients and at the cellular level. The authors associated this variability with genomic, phenotypic, and clinical features and explored the importance of tumors expressing both androgen receptor and neuroendocrine markers. Their findings demonstrate heterogeneity across metastatic sites that may influence treatment response and clinical outcomes, informing future therapeutic strategies in mPC.

• Publisher: American Society for Clinical Investigation
• Subject: Androgen receptors / Androgens / Autopsies / Autopsy / Biomarkers / Biopsy / Cancer / Cancer research / Cancer therapies / Care and treatment / Charitable foundations / Clinical outcomes / Development and progression / DNA methylation / Drug resistance / Genetic Heterogeneity / Humans / Male / Medical research / Metastases / Metastasis / Neoplasm Metastasis / Oncology, Experimental / Patients / Phenotype / Prostate cancer / Prostatic Neoplasms - genetics / Prostatic Neoplasms - metabolism / Prostatic Neoplasms - pathology / Receptors, Androgen - genetics / Receptors, Androgen - metabolism / Treatment resistance / Tumors