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Abundant associations with gene expression complicate GWAS follow-up
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Abundant associations with gene expression complicate GWAS follow-up
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Journal Article
Abundant associations with gene expression complicate GWAS follow-up
2019
Overview
With increasing cohort size and phenotyping, GWAS have identified more than 70,000 associated variants1. Because as many as 90% of GWAS variants fall within non-coding regions, most of them have unknown functional importance2. [...]LocusCompare integrates eQTLs from 48 tissues in the GTEx study (version 7)3; eQTLs and splicing QTLs from coronary artery smooth muscle cells9 and retinal pigment epithelial cells10; and methylation QTLs from brain tissues11,12 and whole blood13. 'Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA. 6Stanford Cardiovascular Institute, Stanford University, Stanford, CA, USA. 7Stanford Diabetes Research Center, Stanford University, Stanford, CA, USA.8Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA. 9
Publisher
Nature Publishing Group US,Nature Publishing Group
Subject
/ 38/91
/ 45
/ 45/43
/ 631/114
/ Animal Genetics and Genomics
/ Biomedical and Life Sciences
/ Brain
/ Datasets
/ Genetics
/ Genome-wide association studies
/ Genome-Wide Association Study - statistics & numerical data
/ Genomics
/ Humans
/ Medicine
/ Methods
/ Muscles
/ Polymorphism, Single Nucleotide
/ Retina
/ Software
/ Splicing
/ Studies
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