Asset Details
Do you wish to reserve the book?
HOTAIR: a key regulator in gynecologic cancers
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
HOTAIR: a key regulator in gynecologic cancers
Do you wish to request the book?
HOTAIR: a key regulator in gynecologic cancers
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
HOTAIR: a key regulator in gynecologic cancers
2017
Overview
Long non-coding RNAs (lncRNAs) play critical roles in the initiation and progression of human cancers. HOX transcript antisense RNA (
HOTAIR
) is an lncRNA localized to the mammalian
HOXC
gene cluster; it can interact with polycomb repressive complex 2 and the lysine-specific histone demethylase/CoREST/REST complex, and it manipulates the expression of various genes.
HOTAIR
promotes tumor invasion and metastasis by silencing tumor suppressors, and activating oncogenes and signaling pathways.
HOTAIR
is deregulated in many human cancers; despite its critical roles in health and disease, the underlying mechanisms governing
HOTAIR
function are unknown. In this review, we summarize the recent findings on the roles of
HOTAIR
in gynecologic cancers.
