Asset Details

MbrlCatalogueTitleDetail

Do you wish to reserve the book?

Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk

by Paternoster, Lavinia , Broer, Linda , Eriksson, Johan G , Hottenga, Jouke J , Luan, Jian'an , Couch, Fergus J , Andrulis, Irene L , Sarkar, Abhishek K , Nutile, Teresa , Harris, Tamara B , Gandin, Ilaria , McCarthy, Mark I , van Dijk, Ko Willems , Stolk, Lisette , Bolla, Manjeet K , Nalls, Mike A , Guénel, Pascal , Peters, Annette , Pedersen, Nancy , Robino, Antonietta , Altmaier, Elisabeth , Benitez, Javier , Brand, Judith S , Navarro, Pau , Wang, Qin , Ruggiero, Daniela , Boutin, Thibaud , Uitterlinden, André G , Campbell, Harry , Lenarduzzi, Stefania , Murray, Anna , Bochud, Murielle , Langenberg, Claudia , Beckmann, Matthias W , Boerwinkle, Eric , Kutalik, Zoltan , Davey Smith, George , Gudbjartsson, Daniel F , Czene, Kamila , Ferrucci, Luigi , Magnusson, Patrik K E , Lind, Penelope A , Rahman, Iffat , Dunning, Alison M , Catamo, Eulalia , Rose, Lynda M , LaChance, Genevieve , Timpson, Nicholas J , Helgason, Hannes , Smith, Albert V , Launer, Lenore J , Palotie, Aarno , Price, Alkes L , Meisinger, Christa , Ulivi, Sheila , Lunetta, Kathryn L , Porteous, David , Hamann, Ute , Edwards, Digna R Velez , Medland, Sarah E , Pouta, Anneli , Dennis, Joe , Wareham, Nichola

in 45/43 / 631/208/205/2138 / 692/699/2732 / 692/699/67 / Adolescent / Age / Age Factors / Agriculture / Animal Genetics and Genomics / Biomedicine / Body mass / Body Mass Index / Breast / Breast cancer / Calcium-Binding Proteins / Cancer / Cancer Research / Carcinogenesis / Children / Coding / Complexity / Databases, Genetic / Diseases / Endocrinology / Endometrial cancer / Endometrium / Enrichment / Epidemiology / Female / Gene expression / Gene Function / Genes / Genetic aspects / Genetic Predisposition to Disease / Genetic variation / Genetics / Genome-Wide Association Study / Genomes / Genomic analysis / Genomic Imprinting / Genomics / Gynecology / Health aspects / Health risks / Heritability / Hospitals / Human Genetics / Humans / Intercellular Signaling Peptides and Proteins - genetics / Internal medicine / Laboratories / Life Sciences / Links / Male / Medical research / Medicine / Membrane Proteins - genetics / Men / Menarche / Menarche - genetics / Mens health / Neoplasms - genetics / Obstetrics / Polygenic inheritance / Polymorphism, Single Nucleotide / Preadipocyte factor 1 / Prostate cancer / Puberty / Puberty - genetics / Public health / Quantitative Trait Loci / Randomization / Ribonucleoproteins - genetics / Risk / Risk Factors / Studies / Time measurement / Transcription / Trends / Ubiquitin-Protein Ligases / Variance / Womens health

2017

Yes Please

Hey, we have placed the reservation for you!

By the way, why not check out events that you can attend while you pick your title.

Oops! Something went wrong.

Looks like we were not able to place the reservation. Kindly try again later.

Are you sure you want to remove the book from the shelf?

Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk

2017

Confirm

Do you wish to request the book?

Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk

2017

Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy

How would you like to get it?

Submit

We have requested the book for you!

Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.

Oops! Something went wrong.

Looks like we were not able to place your request. Kindly try again later.

Journal Article

Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk

Paternoster, Lavinia,

Broer, Linda,

Eriksson, Johan G,

Hottenga, Jouke J,

Luan, Jian'an,

Couch, Fergus J,

Andrulis, Irene L,

Sarkar, Abhishek K,

Nutile, Teresa,

Harris, Tamara B,

Gandin, Ilaria,

McCarthy, Mark I,

van Dijk, Ko Willems,

Stolk, Lisette,

Bolla, Manjeet K,

Nalls, Mike A,

Guénel, Pascal,

Peters, Annette,

Pedersen, Nancy,

Robino, Antonietta,

Altmaier, Elisabeth,

Benitez, Javier,

Brand, Judith S,

Navarro, Pau,

Wang, Qin,

Ruggiero, Daniela,

Boutin, Thibaud,

Uitterlinden, André G,

Campbell, Harry,

Lenarduzzi, Stefania,

Murray, Anna,

Bochud, Murielle,

Langenberg, Claudia,

Beckmann, Matthias W,

Boerwinkle, Eric,

Kutalik, Zoltan,

Davey Smith, George,

Gudbjartsson, Daniel F,

Czene, Kamila,

Ferrucci, Luigi,

Magnusson, Patrik K E,

Lind, Penelope A,

Rahman, Iffat,

Dunning, Alison M,

Catamo, Eulalia,

Rose, Lynda M,

LaChance, Genevieve,

Timpson, Nicholas J,

Helgason, Hannes,

Smith, Albert V,

Launer, Lenore J,

Palotie, Aarno,

Price, Alkes L,

Meisinger, Christa,

Ulivi, Sheila,

Lunetta, Kathryn L,

Porteous, David,

Hamann, Ute,

Edwards, Digna R Velez,

Medland, Sarah E,

Pouta, Anneli,

Dennis, Joe,

Wareham, Nichola

2017

Overview

John Perry, Ken Ong and colleagues analyze genotype data on ∼370,000 women and identify 389 independent signals that associate with age at menarche, implicating ∼250 genes. Their analyses suggest causal inverse associations, independent of BMI, between puberty timing and risks for breast and endometrial cancers in women and prostate cancer in men. The timing of puberty is a highly polygenic childhood trait that is epidemiologically associated with various adult diseases. Using 1000 Genomes Project–imputed genotype data in up to ∼370,000 women, we identify 389 independent signals ( P < 5 × 10 −8 ) for age at menarche, a milestone in female pubertal development. In Icelandic data, these signals explain ∼7.4% of the population variance in age at menarche, corresponding to ∼25% of the estimated heritability. We implicate ∼250 genes via coding variation or associated expression, demonstrating significant enrichment in neural tissues. Rare variants near the imprinted genes MKRN3 and DLK1 were identified, exhibiting large effects when paternally inherited. Mendelian randomization analyses suggest causal inverse associations, independent of body mass index (BMI), between puberty timing and risks for breast and endometrial cancers in women and prostate cancer in men. In aggregate, our findings highlight the complexity of the genetic regulation of puberty timing and support causal links with cancer susceptibility.

Share this book

Add to My Shelf

Publisher

Nature Publishing Group US,Nature Publishing Group

Subject

/ Age