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Circadian Rhythm of Redox State Regulates Excitability in Suprachiasmatic Nucleus Neurons
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Circadian Rhythm of Redox State Regulates Excitability in Suprachiasmatic Nucleus Neurons
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Journal Article
Circadian Rhythm of Redox State Regulates Excitability in Suprachiasmatic Nucleus Neurons
2012
Overview
Daily rhythms of mammalian physiology, metabolism, and behavior parallel the day-night cycle. They are orchestrated by a central circadian clock in the brain, the suprachiasmatic nucleus (SCN). Transcription of clock genes is sensitive to metabolic changes in reduction and oxidation (redox); however, circadian cycles in protein oxidation have been reported in anucleate cells, where no transcription occurs. We investigated whether the SCN also expresses redox cycles and how such metabolic oscillations might affect neuronal physiology. We detected self-sustained circadian rhythms of SCN redox state that required the molecular clockwork. The redox oscillation could determine the excitability of SCN neurons through nontranscriptional modulation of multiple potassium (K + ) channels. Thus, dynamic regulation of SCN excitability appears to be closely tied to metabolism that engages the clockwork machinery.
Publisher
American Association for the Advancement of Science,The American Association for the Advancement of Science
Subject
/ ARNTL Transcription Factors - genetics
/ Biological and medical sciences
/ Brain
/ Channels
/ Firing
/ Fundamental and applied biological sciences. Psychology
/ Joining
/ Mammals
/ Mice
/ Neurons
/ Potassium Channels - metabolism
/ Rats
/ Reagents
/ Suprachiasmatic Nucleus - cytology
/ Suprachiasmatic Nucleus - metabolism
/ Suprachiasmatic Nucleus - physiology
/ T tests
/ Vertebrates: anatomy and physiology, studies on body, several organs or systems
