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Effect of liver resection-induced increases in hepatic venous pressure gradient on development of postoperative acute kidney injury
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Effect of liver resection-induced increases in hepatic venous pressure gradient on development of postoperative acute kidney injury
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Journal Article
Effect of liver resection-induced increases in hepatic venous pressure gradient on development of postoperative acute kidney injury
2022
Overview
Background
The impact of changes in portal pressure before and after liver resection (defined as ΔHVPG) on postoperative kidney function remains unknown. Therefore, we investigated the effect of ΔHVPG on (i) the incidence of postoperative AKI and (ii) the renin-angiotensin system (RAAS) and sympathetic nervous system (SNS) activity.
Methods
We included 30 patients undergoing partial liver resection. Our primary outcome was postoperative AKI according to KDIGO criteria. For our secondary outcome we assessed the plasma renin, aldosterone, noradrenaline, adrenaline, dopamine and vasopressin concentrations prior and 2 h after induction of anaesthesia, on the first and fifth postoperative day. HVPG was measured prior and immediately after liver resection.
Results
ΔHVPG could be measured in 21 patients with 12 patients HVPG showing increases in HVPG (∆HVPG≥1 mmHg) while 9 patients remained stable. AKI developed in 7/12 of patients with increasing HVPG, but only in 2/9 of patients with stable ΔHVPG (
p
= 0.302). Noradrenalin levels were significantly higher in patients with increasing ΔHVPG than in patients with stable ΔHVPG. (
p
= 0.009). Biomarkers reflecting RAAS and SNS activity remained similar in patients with increasing vs. stable ΔHVPG.
Conclusions
Patients with increased HVPG had higher postoperative creatinine concentrations, however, the incidence of AKI was similar between patients with increased versus stable HVPG.
Publisher
BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
Subject
/ Acute Kidney Injury - epidemiology
/ Acute Kidney Injury - etiology
/ Adult
/ Aged
/ Analysis
/ Complications and side effects
/ Dopamine
/ Female
/ Fentanyl
/ Hepatic venous pressure gradient
/ Humans
/ Kidneys
/ Liver
/ Male
/ Medicine
/ Patients
/ Postoperative Complications - epidemiology
/ Postoperative Complications - etiology
/ Renin
/ Renin-Angiotensin System - physiology
/ Renin-angiotensin-aldosterone system
/ Surgery
