Journal Article

Direct healthcare resource utilisation, health-related quality of life, and work productivity in patients with moderate rheumatoid arthritis: an observational study

Bhagat, Shweta, Galloway, James, Blanthorn-Hazell, Sophee, Cole, Zoe, Maxwell, James, Parker, Ben, Tan, Ai Lyn, Bellamy, Claire, Edwards, Julie, Wallington, Mike

2021

Overview

Background The aim was to describe the population of patients with moderate rheumatoid arthritis (RA) in the United Kingdom and the burden of disease from the perspectives of the patient, caregiver, and health service. Methods In this descriptive study, retrospective patient-level data were extracted from hospital medical records to assess healthcare resource utilisation and validated outcome measures were administered via questionnaire to patients with moderate RA (Disease Activity Score [DAS28] between 3.2 and 5.1) from eight secondary care centres, and their caregivers. Patient-reported outcome instruments were scored according to licensed manuals. Results Outcome measures were completed by 102 patients and 38 caregivers. The mean EuroQoL-5 dimension-5 level crosswalk index value for patients was 0.62 (SD 0.24) compared to an England population norm of 0.82. Mean pain VAS score was 37.7 (SD 24.0) and mean Health Assessment Questionnaire Disability Index was 1.1 (SD 0.8). In employed patients who completed the Work Productivity and Activity Impairment questionnaire ( n  = 26), a mean 29% (SD 26%) reduction in work productivity was recorded. Patients experienced significant fatigue as a result of their RA (median Functional Assessment of Chronic Illness Therapy fatigue score 17.2 of a possible 52, interquartile range [IQR] 11.0–28.8). Over 50% of caregivers reported providing > 7 h of support care per week to the patient with RA, and 16 and 11% took paid/unpaid leave or reduced working hours, respectively. Mean Caregiver Reaction Assessment subscale scores were 1.9 (SD 0.9) for finance, 1.7 (SD 0.8) for health, 2.3 (SD 1.0) for schedule disruption, and 1.9 (SD 0.8) for family support. Patients had a mean 5.5 (SD 4.1) outpatient attendances and a median 9.0 (IQR 2.0–20.0) diagnostic and monitoring tests in the 12 months prior to enrolment. Conclusions This study shows that moderate RA has a considerable impact on healthcare resources and on patients’ and caregivers’ lives. There is scope to improve the management of patients with moderate RA.

• Publisher: BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
• Subject: Arthritics / Arthritis, Rheumatoid - diagnosis / Arthritis, Rheumatoid - epidemiology / Arthritis, Rheumatoid - therapy / Burden / Care and treatment / Caregivers / Chronic illnesses / Clinical rheumatology and osteoporosis / Consent / Cost control / DAS28 / Delivery of Health Care / Disability / Economic aspects / Employment / England - epidemiology / Epidemiology / EQ-5D / Fatigue / Health aspects / Humans / Internal Medicine / Labor productivity / Medical care / Medical records / Medicine / Medicine & Public Health / Moderate / Musculoskeletal diseases / Observational studies / Orthopedics / Pain / Patients / Productivity / Quality of Life / Questionnaires / Rehabilitation / Research Article / Retrospective Studies / Rheumatoid arthritis / Rheumatology / Severity of Illness Index / Sports Medicine / Surveys / Surveys and Questionnaires / United Kingdom - epidemiology / Utilization