Journal Article

The role of m6A RNA methylation in cancer metabolism

An, Yuanyuan, Duan, Hua

2022

Overview

Metabolic reprogramming is one of the main characteristics of malignant tumors, which is due to the flexible changes of cell metabolism that can meet the needs of cell growth and maintain the homeostasis of tissue environments. Cancer cells can obtain metabolic adaptation through a variety of endogenous and exogenous signaling pathways, which can not only promote the growth of malignant cancer cells, but also start the transformation process of cells to adapt to tumor microenvironment. Studies show that m6A RNA methylation is widely involved in the metabolic recombination of tumor cells. In eukaryotes, m6A methylation is the most abundant modification in mRNA, which is involved in almost all the RNA cycle stages, including regulation the transcription, maturation, translation, degradation and stability of mRNA. M6A RNA methylation can be involved in the regulation of physiological and pathological processes, including cancer. In this review, we discuss the role of m6A RNA methylation modification plays in tumor metabolism-related molecules and pathways, aiming to show the importance of targeting m6A in regulating tumor metabolism.

• Publisher: BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
• Subject: Adenosine - analogs & derivatives / Adenosine - metabolism / Animals / Biomarkers / Biomedical and Life Sciences / Biomedicine / Biosynthesis / Cancer / Cancer Research / Cell growth / Chemotherapy / Disease Management / Disease Susceptibility / Energy / Energy Metabolism / Enzymes / Epigenetics / Gene expression / Gene Expression Regulation, Neoplastic / Gene regulation / Genetic transcription / Glucose / Homeostasis / Humans / Hypoxia / Metabolism / Metabolism reprogramming / Metabolites / Metastasis / Methylation / Methyltransferases / Mitochondria - genetics / Mitochondria - metabolism / mRNA stability / Mutation / N6-methyladenosine / Neoplasms - etiology / Neoplasms - metabolism / Neoplasms - pathology / Neoplasms - therapy / Oncology / Physiological aspects / Recombination / Review / RNA / RNA - genetics / RNA - metabolism / RNA modification / RNA Processing, Post-Transcriptional / RNA, Circular / RNA, Messenger / RNA, Untranslated / Signal Transduction / The m6A / Transcription / Transcription Factors / Tumor cells / Tumor microenvironment / Tumors