Journal Article

Prevalence and the associated factors of hepatitis B and hepatitis C viral infections among HIV-positive individuals in same-day antiretroviral therapy initiation program in Bangkok, Thailand

Avihingsanon, Anchalee, Phanuphak, Praphan, Phanuphak, Nittaya, Pankam, Tippawan, Avery, Matthew, Seekaew, Pich, Amatavete, Sorawit, Sangsai, Monsiri, Thitipatarakorn, Supanat, Chinbunchorn, Tanat, Peelay, Jitsupa, Ramautarsing, Reshmie

2022

Overview

Background Viral hepatitis is highly prevalent among people with HIV (PWH) and can lead to chronic liver complications. Thailand started universal hepatitis B vaccination at birth in 1992 and achieved over 95% coverage in 1999. We explored the prevalence of hepatitis B and C viral infections and the associated factors among PWH from same-day antiretroviral therapy (SDART) service at the Thai Red Cross Anonymous Clinic, Bangkok, Thailand. Methods We collected baseline characteristics from PWH enrolled in the SDART service between July 2017 and November 2019. Multivariable logistic regression was performed to determine factors associated with positive hepatitis B surface antigen (HBsAg) and hepatitis C antibody (anti-HCV). Results A total of 4011 newly diagnosed PWH who had HBsAg or anti-HCV results at baseline: 2941 men who have sex with men (MSM; 73.3%), 851 heterosexuals (21.2%), 215 transgender women (TGW; 5.4%), and 4 transgender men (0.1%). Median age was 27 years. Overall seroprevalence of HBsAg and anti-HCV were 6.0 and 4.1%, respectively. Subgroup prevalence were 6.2 and 4.7% among MSM, 4.6 and 2.4% among heterosexuals, and 9.3 and 3.7% among TGW, respectively. Factors associated with HBsAg positivity were being MSM, TGW, born before 1992, CD4 count < 200 cells/mm 3 , and alanine aminotransferase ≥ 62.5 U/L. Factors associated with anti-HCV positivity were being MSM, age > 30 years, alanine aminotransferase ≥ 62.5 U/L, creatinine clearance < 60 ml/min, and syphilis infection. Conclusions Around 5–10% of newly diagnosed PWH in Bangkok had hepatitis B viral infection after 25 years of universal vaccination. Anti-HCV positivity was found in 4–5% of PWH who were MSM and TGW. As World Health Organization and Thailand national guidelines already support routine screening of hepatitis B and C viral infections in PWH and populations at increased risk of HIV including MSM and TGW, healthcare providers should reinforce this strategy and provide linkage to appropriate prevention and treatment interventions. Catch-up hepatitis B vaccination should be made available under national health coverage.

• Publisher: BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
• Subject: Acquired immune deficiency syndrome / Adult / Age / AIDS / Alanine / Alanine Transaminase / Anti-Retroviral Agents - therapeutic use / Antibodies / Antigens / Antiretroviral agents / Antiretroviral drugs / Antiretroviral therapy / Biostatistics / CD4 antigen / Creatinine / Demographic aspects / Diagnosis / Drug therapy / Drug use / Environmental Health / Epidemiology / Female / Health care / Hepacivirus / Hepatitis / Hepatitis B / Hepatitis B - complications / Hepatitis B - epidemiology / Hepatitis B surface antigen / Hepatitis B Surface Antigens / Hepatitis C / Hepatitis C - complications / Hepatitis C - epidemiology / Hepatitis C Antibodies / HIV / HIV Infections - complications / HIV Infections - drug therapy / HIV Infections - epidemiology / HIV patients / Homosexuality, Male / Human immunodeficiency virus / Humans / Immunization / Immunoassay / Infant, Newborn / Infections / Laboratories / Male / Medical examination / Medicine / Medicine & Public Health / Men / Population / Prevalence / Public Health / Risk factors / Seroepidemiologic Studies / Serology / Sexual and Gender Minorities / Sexually transmitted diseases / STD / Subgroups / Syphilis / Thailand - epidemiology / Transaminases / Transgender persons / Vaccination / Vaccine / Viral hepatitis vaccines / Viral infections