Journal Article

Effects of probiotics on type II diabetes mellitus: a meta-analysis

Gu, Ying-Luo, Zhang, Lei, Mao, Xin-Qi, Pei, Yu-Fang, Tao, Yun-Wen

2020

Overview

Objective The purpose of the present study was to evaluate the effectiveness of probiotics on type II diabetes mellitus (T2DM). Methods We performed a comprehensive search on PubMed, Web of Science, China National Knowledge Infrastructure, Chinese Scientific Journal Databases, Wan Fang database and China biology medicine disc for relevant studies published before June 2019. Glycated hemoglobin A1c (HbA1c), homeostasis model assessment of insulin resistance (HOMA-IR) and fasting blood glucose (FBG) were used as indicators for T2DM. Inverse-variance weighted mean difference (WMD) with 95% confidence interval (CI) was calculated for the mean HbA1c, FBG and HOMA-IR changes from baseline. Results 15 randomized controlled trials (RCT) with a total of 902 participants were included into the meta-analysis. Considering the clinical heterogeneity caused by variation of dosage and duration of probiotic treatment, random-effects model was used to estimate the pooled WMD. Significantly greater reduction in HbA1c% (WMD = − 0.24, 95% CI [− 0.44, − 0.04], p  = 0.02), FBG (WMD = − 0.44 mmol/L, 95% CI [− 0.74, − 0.15], p  = 0.003) and HOMA-IR (WMD = − 1.07, 95% CI [− 1.58, − 0.56], p  < 0.00001) were observed in probiotics treated group. Further sensitivity analysis verified the reliability and stability of our results. Conclusion The results of our meta-analysis indicated that probiotics treatment may reduce HbA1c, FBG and insulin resistance level in T2DM patients. More clinical data and research into the mechanism of probiotics are needed to clarify the role of probiotics in T2DM.

• Publisher: BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
• Subject: Bias / Biomedical and Life Sciences / Biomedicine / Blood Glucose / Care and treatment / China / Clinical trials / Diabetes / Diabetes mellitus / Diabetes Mellitus, Type 2 - therapy / Diabetes research / Gastrointestinal agents / Glucose / Glycated Hemoglobin A / Glycosylated hemoglobin / Gut microbiota / Health aspects / Hemoglobin / Hemoglobins / Homeostasis / Humans / Infrastructure (Economics) / Insulin / Insulin resistance / Medical nutrition therapy / Medical research / Medicine/Public Health / Meta-analysis / Metabolism / Microbiota / Microbiota (Symbiotic organisms) / Nutrition & metabolism / Pathogenesis / Peptides / Probiotic / Probiotics / Probiotics - therapeutic use / Quality / Randomized Controlled Trials as Topic / Review / Sensitivity analysis / Software / Studies / Type 2 diabetes / Type II diabetes mellitus