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Associations between myeloperoxidase and paraoxonase-1 and type 2 diabetes in patients with ischemic heart disease
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Associations between myeloperoxidase and paraoxonase-1 and type 2 diabetes in patients with ischemic heart disease
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Journal Article
Associations between myeloperoxidase and paraoxonase-1 and type 2 diabetes in patients with ischemic heart disease
2022
Overview
Background
The phrase “dysfunctional high-density lipoprotein” has been developed in the literature to describe the particle which loses its basic role- anti-oxidative and anti-inflammatory activity. In this porcess, the significance of enzymes- pro-oxidant myeloperoxidase (MPO) and antioxidant paraoxonase-1 (PON-1) from the perspective of HDL-C function has been noted.
Aims
The objective of this study was to analyze the associations between two enzymes –MPO and PON-1 and type 2 diabetes (T2DM) in patients with ischemic heart disease (IHD).
Methods
An observational cross-sectional study including 70 patients with IHD of whom 35 had also T2DM, and 35 had no T2DM. Laboratory tests (MPO, PON-1, fasting glucose, glycated hemoglobin, total cholesterol, triglycerides, high-density lipoprotein, low-density lipoprotein, and high-sensitivity C-reactive protein) were performed.
Results
The study revealed a significant difference in the serum concentration of the enzymes between patients with IHD with and without T2DM. Our results showed increased MPO concentration levels in diabetic patients. The analysis also revealed that T2DM is independently associated with an increase in MPO levels. Simultaneously, a decrease in PON-1 levels was observed in patients with T2DM. The study also revealed that T2DM is independently associated with a decrease in PON-1 levels.
Conclusions
In patients with type 2 diabetes the profile of enzymes involved in high-density lipoprotein metabolism in patients with IHD is worse than in patients without T2DM. The increase in the levels of MPO, an enzyme with oxidative and atherogenic properties and on a decrease in PON-1 levels, an enzyme with antioxidant and atheroprotective properties is observed.
Publisher
BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
Subject
/ Aryldialkylphosphatase - metabolism
/ Blood
/ Complications and side effects
/ Diabetes
/ Diabetes mellitus (non-insulin dependent)
/ Diabetes Mellitus, Type 2 - complications
/ Diabetes Mellitus, Type 2 - enzymology
/ Diabetes Mellitus, Type 2 - metabolism
/ Dysfunctional high-density lipoprotein
/ Enzymes
/ Heart
/ Humans
/ Ischemia
/ Lipoproteins, HDL - metabolism
/ Medicine
/ Myocardial Ischemia - complications
/ Myocardial Ischemia - enzymology
/ Myocardial Ischemia - metabolism
/ Oxidants
/ Patients
/ Plasma
/ Smoking
