Asset Details
Do you wish to reserve the book?
T lymphocyte senescence is attenuated in Parkinson’s disease
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
T lymphocyte senescence is attenuated in Parkinson’s disease
Do you wish to request the book?
T lymphocyte senescence is attenuated in Parkinson’s disease
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
T lymphocyte senescence is attenuated in Parkinson’s disease
2021
Overview
Background
Immune involvement is well-described in Parkinson’s disease (PD), including an adaptive T lymphocyte response. Given the increasing prevalence of Parkinson’s disease in older age, age-related dysregulation of T lymphocytes may be relevant in this disorder, and we have previously observed changes in age-associated CD8
+
T cell subsets in mid-stage PD. This study aimed to further characterise T cell immunosenescence in newly diagnosed PD patients, including shifts in CD4
+
and CD8
+
subpopulations, and changes in markers of cellular ageing in CD8
+
T lymphocytes.
Methods
Peripheral blood mononuclear cells were extracted from the blood of 61 newly diagnosed PD patients and 63 age- and sex-matched controls. Flow cytometric analysis was used for immunophenotyping of CD8
+
and CD4
+
lymphocyte subsets, and analysis of recent thymic emigrant cells. Telomere length within CD8
+
T lymphocytes was assessed, as well as the expression of the telomerase reverse transcriptase enzyme (hTERT), and the cell-ageing markers p16
INK4a
and p21
CIP1/Waf1
.
Results
The number of CD8
+
TEMRA T cells was found to be significantly reduced in PD patients compared to controls. The expression of p16
INK4a
in CD8
+
lymphocytes was also lower in patients versus controls. Chronic latent CMV infection was associated with increased senescent CD8
+
lymphocytes in healthy controls, but this shift was less apparent in PD patients.
Conclusions
Taken together, our data demonstrate a reduction in CD8
+
T cell replicative senescence which is present at the earliest stages of Parkinson’s disease.
Publisher
BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
Subject
/ Aging
/ Biomedical and Life Sciences
/ CD8-Positive T-Lymphocytes - immunology
/ CD8-Positive T-Lymphocytes - metabolism
/ CD8-Positive T-Lymphocytes - pathology
/ Cellular Senescence - physiology
/ Cyclin-dependent kinase inhibitor p21
/ Female
/ Humans
/ Kinases
/ Leukocytes, Mononuclear - immunology
/ Leukocytes, Mononuclear - metabolism
/ Leukocytes, Mononuclear - pathology
/ Male
/ Parkinson Disease - immunology
/ Parkinson Disease - metabolism
/ Parkinson Disease - pathology
/ Peripheral blood mononuclear cells
/ T cells
/ Telomerase reverse transcriptase
/ Thymus
