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Bilophila wadsworthia aggravates high fat diet induced metabolic dysfunctions in mice
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Bilophila wadsworthia aggravates high fat diet induced metabolic dysfunctions in mice
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Journal Article
Bilophila wadsworthia aggravates high fat diet induced metabolic dysfunctions in mice
2018
Overview
Dietary lipids favor the growth of the pathobiont
Bilophila wadsworthia
, but the relevance of this expansion in metabolic syndrome pathogenesis is poorly understood. Here, we showed that
B. wadsworthia
synergizes with high fat diet (HFD) to promote higher inflammation, intestinal barrier dysfunction and bile acid dysmetabolism, leading to higher glucose dysmetabolism and hepatic steatosis. Host-microbiota transcriptomics analysis reveal pathways, particularly butanoate metabolism, which may underlie the metabolic effects mediated by
B. wadsworthia
. Pharmacological suppression of
B. wadsworthia-
associated inflammation demonstrate the bacterium’s intrinsic capacity to induce a negative impact on glycemic control and hepatic function. Administration of the probiotic
Lactobacillus rhamnosus
CNCM I-3690 limits
B. wadsworthia-
induced immune and metabolic impairment by limiting its expansion, reducing inflammation and reinforcing intestinal barrier. Our results suggest a new avenue for interventions against western diet-driven inflammatory and metabolic diseases.
Lipid intake is known to promote
Bilophila wadsworthia
growth. Here the authors show that
B. wadsworthia
aggravates high fat diet induced metabolic dysfunctions and its suppression, both pharmacologically or mediated by
Lactobacillus rhamnosus
, limits the severity of metabolic impairment.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 38/91
/ Animals
/ Bilophila - growth & development
/ Desulfovibrionaceae Infections - etiology
/ Desulfovibrionaceae Infections - metabolism
/ Desulfovibrionaceae Infections - microbiology
/ Desulfovibrionaceae Infections - therapy
/ Diet
/ Diet, High-Fat - adverse effects
/ Dietary Fats - adverse effects
/ Endocrinology and metabolism
/ Humanities and Social Sciences
/ Lactobacillus rhamnosus - physiology
/ Lipids
/ Male
/ Metabolic Networks and Pathways - genetics
/ Metabolic Syndrome - etiology
/ Metabolic Syndrome - metabolism
/ Metabolic Syndrome - microbiology
/ Metabolic Syndrome - therapy
/ Mice
/ Science
