Journal Article

Perinatal outcomes and growth discordance of triplet pregnancies based on chorionicity: a retrospective cohort study

Yu, Haiyan, Zeng, Zhaomin, Liao, Hua, Xu, Tingting, Hu, Qing, Liu, Hongyan

2024

Overview

Background The worldwide occurrence of triplet pregnancy is estimated to be 0.093%, with a natural incidence of approximately 1 in 8000. This study aims to analyze the neonatal health status and birth weight discordance (BWD) of triplets based on chorionicity from birth until discharge. Methods This was a retrospective study. We reviewed a total of 136 triplet pregnancies at our tertiary hospital between January 1, 2001, and December 31, 2021. Maternal and neonatal outcomes, inter-triplet BWD, neonatal morbidity, and mortality were analyzed. Results Among all cases, the rates of intrauterine death, neonatal death, and perinatal death were 10.29, 13.07, and 24.26%, respectively. Thirty-seven of the cases resulted in fetal loss, including 13 with fetal anomalies. The maternal complications and neonatal outcomes of the 99 triplet pregnancies without fetal loss were compared across different chorionicities, including a dichorionic (DC) group (41 cases), trichorionic (TC) group (37 cases), and monochorionic (MC) group (21 cases). Neonatal hypoproteinemia ( P  < 0.001), hyperbilirubinemia ( P  < 0.019), and anemia ( P  < 0.003) exhibited significant differences according to chorionicity, as did the distribution of BWD ( P  < 0.001). More than half of the cases in the DC and TC groups had a BWD < 15%, while those in the MC group had a BWD < 50% (47.6%). TC pregnancy decreased the risk of neonatal anemia (adjusted odds ratio [AOR] = 0.084) and need for blood transfusion therapy after birth (AOR = 0.119). In contrast, a BWD > 25% increased the risk of neonatal anemia (AOR = 10.135) and need for blood transfusion after birth (AOR = 7.127). TC pregnancy, MCDA or MCTA, and BWD > 25% increased neonatal hypoproteinemia, with AORs of 4.629, 5.123, and 5.343, respectively. Conclusions The BWD differed significantly according to chorionicity. Additionally, TC pregnancies reduced the risk of neonatal anemia and need for blood transfusion, but increased the risk of neonatal hypoproteinemia. In contrast, the BWD between the largest and smallest triplets increased the risk of neonatal anemia and the need for blood transfusion. TC pregnancy, MCDA or MCTA, and BWD > 25% increased the risks of neonatal hypoproteinemia. However, due to the limited number of triplet pregnancies, further exploration of the underlying mechanism is warranted.

• Publisher: BioMed Central,Springer Nature B.V,BMC
• Subject: Abortion / Adult / Birth Weight / Birth weight discordance / Chorion / Cohort analysis / Dichorionic triplets / Female / Fetal Death - etiology / Fetuses / Gestational age / Gynecology / Humans / Infant, Newborn / Maternal and Child Health / Medical prognosis / Medical records / Medicine / Medicine & Public Health / Monochorionic triplets / Morbidity / Perinatal outcomes / Pregnancy / Pregnancy Outcome - epidemiology / Pregnancy, Triplet / Reproductive Medicine / Retrospective Studies / Trichorionic triplets / Triplet pregnancy / Triplets / Twins / Ultrasonic imaging