Journal Article

Multimodal lung cancer theranostics via manganese phosphate/quercetin particle

Tu, Qingchao, Han, Guang, Hou, Yichong, Yan, Jiawei, Chen, Weiqi, Zhong, Linying, Fu, Yuanfeng, Tang, Huan, Xia, Fei, Zou, Li, Liu, Yinan, Meng, Yuqing, Qiu, Chong, Yao, HaiLu, Zhang, Junzhe, Zhou, Xinyu, Gan, Licheng, Liu, Hongda, Wang, Chen, Guo, Pengbo, Shi, Qiaoli, Wang, Jigang, Pang, Huanhuan, Wang, Xijun

2025

Overview

The diagnosis and treatment of non-small cell lung cancer in clinical settings face serious challenges, particularly due to the lack of integration between the two processes, which limit real-time adjustments in treatment plans based on the patient’s condition and drive-up treatment costs. Here, we present a multifunctional pH-sensitive core-shell nanoparticle containing quercetin (QCT), termed AHA@MnP/QCT NPs, designed for the simultaneous diagnosis and treatment of non-small cell lung cancer. Mechanistic studies indicated that QCT and Mn 2+ exhibited excellent peroxidase-like (POD-like) activity, catalysing the conversion of endogenous hydrogen peroxide into highly toxic hydroxyl radicals through a Fenton-like reaction, depleting glutathione (GSH), promoting reactive oxygen species (ROS) generation in mitochondria and endoplasmic reticulum, and inducing ferroptosis. Additionally, Mn 2+ could activate the cGAS-STING signalling pathway and promote the maturation of dendritic cells and infiltration of activated T cells, thus inducing tumor immunogenic cell death (ICD). Furthermore, it exhibited effective T2-weighted MRI enhancement for tumor imaging, making them valuable for clinical diagnosis. In vitro and in vivo experiments demonstrated that AHA@MnP/QCT NPs enabled non-invasive imaging and tumor treatment, which presented a one-stone-for-two-birds strategy for combining tumor diagnosis and treatment, with broad potential for clinical application in non-small cell lung cancer therapy. Graphical Abstract

• Publisher: BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
• Subject: Advance in Nanomedicine for Cancer Therapy / Animals / Antitumor therapy / Apoptosis / Bioavailability / Biomedical and Life Sciences / Biomedicine / Cancer Research / Cancer therapies / Carcinoma, Non-Small-Cell Lung - drug therapy / Care and treatment / Cell death / Cell Line, Tumor / Chemotherapy / Dendritic cells / Diagnosis / Efficiency / Endoplasmic reticulum / Ferroptosis / Fourier transforms / Free radicals / Glutathione / Humans / Hyaluronic acid / Hydrogen peroxide / Hydroxyl radicals / Immunogenicity / Integrated diagnosis and treatment / Lung cancer / Lung cancer, Non-small cell / Lung Neoplasms - diagnosis / Lung Neoplasms - diagnostic imaging / Lung Neoplasms - drug therapy / Lung Neoplasms - metabolism / Lung Neoplasms - pathology / Lymphocytes / Lymphocytes T / Magnetic Resonance Imaging / Manganese / Manganese - chemistry / Manganese Compounds - chemistry / Manganese phosphate / Medical diagnosis / Metastases / Mice / Microscopy / Mineralization / Mortality / Nanoparticles / Nanoparticles - chemistry / Non-small cell lung carcinoma / Oncology / Particle size / pH effects / Phosphates / Polyethylene glycol / Polymers / Precision medicine / Quercetin / Quercetin - chemistry / Quercetin - pharmacology / Radiation therapy / Reactive oxygen species / Reactive Oxygen Species - metabolism / Signal transduction / Small cell lung carcinoma / T cells / Theranostic Nanomedicine - methods / Toxicity / Traditional Chinese medicine / Tumors / Vincristine / Xenograft Model Antitumor Assays