Journal Article

High level of fluorescent oxidation products and worsening of asthma control over time

Le Moual, Nicole, Zerimech, Farid, Akiki, Zeina, Andrianjafimasy, Miora, Siroux, Valérie, Matran, Régis, Nadif, Rachel, Dumas, Orianne

2019

Overview

High Fluorescent oxidation products level (FlOPs), a global oxidative stress biomarker, was associated cross-sectionally with poor asthma outcomes but its longitudinal association with asthma evolution has never been examined. We aimed to study the associations between FlOPs level at baseline and changes in current asthma, asthma attacks and asthma control status over 8 years. We used data from the second survey of the French EGEA cohort study as baseline and the third survey as follow-up. At baseline, the mean age of the 489 participants with ever asthma was 39 (± 16) years, 49% were women. Among participants with controlled asthma at baseline, high FlOPs level was significantly associated with worsening of asthma control at follow-up (odds-ratio adjusted for age, sex and smoking status (95% CI): 2.27 (1.32–3.90). No other significant associations were observed. In conclusion, results suggest FlOPs as a predictor of asthma evolution in adults and a good candidate marker in asthma management.

• Publisher: BioMed Central,BioMed Central Ltd,Nature Publishing Group,BMC
• Subject: Adult / Adult asthma / Asthma / Asthma - diagnosis / Asthma - epidemiology / Asthma - metabolism / Asthma control / Biomarkers / Cohort Studies / Development and progression / Disease Progression / Epidemiology / Evolution / Female / Fluorescence / Fluorescent oxidation products / Health aspects / Humans / Letter to the Editor / Life Sciences / Longitude / Longitudinal studies / Longitudinal study / Male / Medicine / Medicine & Public Health / Middle Aged / Oxidation / Oxidation-Reduction / Oxidative stress / Oxidative Stress - physiology / Pneumology/Respiratory System / Polls & surveys / Santé publique et épidémiologie / Sex ratio / Smoking / Young Adult