Journal Article

Faecal microbiota of schoolchildren is associated with nutritional status and markers of inflammation: a double-blinded cluster-randomized controlled trial using multi-micronutrient fortified rice

Burja, Kurt, Humblot, Christèle, Turpin, Williams, Fiorentino, Marion, Démarche intégrée pour l'obtention d'aliments de qualité (UMR QualiSud) ; Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut de Recherche pour le Développement (IRD)-Avignon Université (AU)-Université de La Réunion (UR)-Institut Agro Montpellier ; Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Université de Montpellier (UM), Chamnan, Chhoun, Kuong, Khov, Seyoum, Yohannes, Universiteit van Amsterdam = University of Amsterdam (UvA), University of Toronto, Ponce, Maiza Campos, Chochois, Vincent, Montpellier Interdisciplinary center on Sustainable Agri-food systems (Social and nutritional sciences) (UMR MoISA) ; Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut de Rech

2024

Overview

Faecal microbiota plays a critical role in human health, but its relationship with nutritional status among schoolchildren remains under-explored. Here, in a double-blinded cluster-randomized controlled trial on 380 Cambodian schoolchildren, we characterize the impact of six months consumption of two types of rice fortified with different levels of vitamins and minerals on pre-specified outcomes. We investigate the association between the faecal microbiota (16SrRNA sequencing) and age, sex, nutritional status (underweight, stunting), micronutrient status (iron, zinc and vitamin A deficiencies, anaemia, iron deficient anaemia, hemoglobinopathy), inflammation (systemic, gut), and parasitic infection. We show that the faecal microbiota is characterised by a surprisingly high proportion of Lactobacillaceae . We discover that deficiencies in specific micronutrients, such as iron and vitamin A, correlate with particular microbiota profiles, whereas zinc deficiency shows no such association. The nutritional intervention with the two rice treatments impacts both the composition and functions predicted from compositional analysis in different ways. (ClinicalTrials.gov (Identifier: NCT01706419))

• Publisher: Nature Publishing Group,CCSD,Nature Publishing Group UK,Nature Portfolio
• Subject: 49/23 / 631/326/2565/2142 / 692/699/1702/295 / 82/1 / Adolescent / Anemia / Biomarkers - blood / Body weight / Child / Clinical trials / Clusters / Deficiency diseases / Double-Blind Method / Fecal microflora / Feces - microbiology / Female / Food and Nutrition / Food, Fortified / Gastrointestinal Microbiome - drug effects / Hemoglobinopathy / Humanities and Social Sciences / Humans / Inflammation / Iron / Iron deficiency / Life Sciences / Male / Microbiota / Micronutrients / Microorganisms / multidisciplinary / Nutrient deficiency / Nutritional Status / Oryza / Parasitic diseases / Retinene / Rice / Science / Science (multidisciplinary) / Underweight / Vitamin A / Vitamin A - administration & dosage / Vitamin A - blood / Vitamin deficiency / Vitamins / Zinc / Zinc - deficiency
• ISBN: 0012508114000