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The tail domain of PRRSV NSP2 plays a key role in aggrephagy by interacting with 14-3-3ε
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The tail domain of PRRSV NSP2 plays a key role in aggrephagy by interacting with 14-3-3ε
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Journal Article
The tail domain of PRRSV NSP2 plays a key role in aggrephagy by interacting with 14-3-3ε
2020
Overview
Porcine reproductive and respiratory syndrome (PRRS) caused by PRRS virus (PRRSV) is one of the most severe swine diseases that affects almost all swine-breeding countries. Nonstructural protein 2 (NSP2) is one of the most important viral proteins in the PRRSV life cycle. Our previous study showed that PRRSV NSP2 could induce the formation of aggresomes. In this study we explored the effects of aggresome formation on cells and found that NSP2 could induce autophagy, which depended on aggresome formation to activate aggrephagy. The transmembrane and tail domains of NSP2 contributed to aggrephagy and the cellular protein 14-3-3ε played an important role in NSP2-induced autophagy by binding the tail domain of NSP2. These findings provide information on the function of the C-terminal domain of NSP2, which will help uncover the function of NSP2 during PRRSV infection.
Publisher
BioMed Central,Springer Nature B.V,BMC
Subject
/ 14-3-3ε
/ Animals
/ Cloning
/ Genomes
/ Medicine
/ Mutation
/ NSP2
/ Plasmids
/ porcine reproductive and respiratory syndrome
/ Porcine Reproductive and Respiratory Syndrome - microbiology
/ Porcine respiratory and reproductive syndrome virus - genetics
/ Porcine respiratory and reproductive syndrome virus - physiology
/ Proteins
/ PRRSV
/ Reagents
/ Swine
/ Transmission electron microscopy
/ Veterinary Medicine/Veterinary Science
/ viral nonstructural proteins
/ Virology
/ Viruses
