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Obesity-related loci in TMEM18, CDKAL1 and FAIM2 are associated with obesity and type 2 diabetes in Chinese Han patients
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Obesity-related loci in TMEM18, CDKAL1 and FAIM2 are associated with obesity and type 2 diabetes in Chinese Han patients
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Journal Article
Obesity-related loci in TMEM18, CDKAL1 and FAIM2 are associated with obesity and type 2 diabetes in Chinese Han patients
2020
Overview
Background
Several obesity susceptibility loci in genes, including
GNPDA2
,
SH2B1
,
TMEM18
,
MTCH2
,
CDKAL1
,
FAIM2
, and
MC4R
, have been identified by genome-wide association studies. The purpose of this study was to investigate whether these loci are associated with the concurrence of obesity and type 2 diabetes in Chinese Han patients.
Methods
Using the SNaPshot technique, we genotyped seven single nucleotide polymorphisms (SNPs) in 439 Chinese patients living in Northeast China who presented at The Second Hospital of Jilin University. We analyzed the associations between these seven alleles and clinical characteristics.
Results
Risk alleles near
TMEM18
(rs6548238) were associated with increased waist circumference, waist/hip ratio, body mass index (BMI), fasting plasma glucose, hemoglobin A1c, diastolic blood pressure, triglycerides, total cholesterol, and low-density lipoprotein-cholesterol; risk alleles of
CDKAL1
(rs7754840) were associated with increased waist circumference and waist/hip ratio; and
FAIM2
(rs7138803) risk alleles were linked to increased BMI, diastolic blood pressure, and triglycerides (all
P
< 0.05). After adjusting for sex and age, loci near
TMEM18
(rs6548238) and
FAIM2
(rs7138803), but not
SH2B1
(rs7498665), near
GNPDA2
(rs10938397),
MTCH2
(rs10838738) and near
MC4R
(rs12970134), were associated with increased risk for type 2 diabetes in obese individuals.
Conclusion
We found that loci near
TMEM18
(rs6548238),
CDKAL1
(rs7754840), and
FAIM2
(rs7138803) may be associated with obesity-related indicators, and loci near
TMEM18
(rs6548238) and
FAIM2
(rs7138803) may increase susceptibility of concurrent type 2 diabetes associated with obesity.
Publisher
BioMed Central,BioMed Central Ltd,BMC
Subject
/ Adult
/ Age
/ Aged
/ Alleles
/ Analysis
/ Apoptosis Regulatory Proteins - genetics
/ Asian Continental Ancestry Group - ethnology
/ Asian Continental Ancestry Group - genetics
/ Biomedical and Life Sciences
/ Diabetes
/ Diabetes mellitus (non-insulin dependent)
/ Diabetes Mellitus, Type 2 - complications
/ Diabetes Mellitus, Type 2 - ethnology
/ Diabetes Mellitus, Type 2 - genetics
/ Female
/ Genetic epidemiology and genetic associations
/ Genetic Predisposition to Disease
/ Genome-wide association studies
/ Genome-Wide Association Study
/ Genomes
/ Genomics
/ Hip
/ Humans
/ Male
/ Membrane Proteins - genetics
/ Obesity
/ Patients
/ Polymorphism, Single Nucleotide
/ Single nucleotide polymorphisms
/ Single-nucleotide polymorphism
/ SNP
