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RNA transport and local translation in neurodevelopmental and neurodegenerative disease
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RNA transport and local translation in neurodevelopmental and neurodegenerative disease
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Journal Article
RNA transport and local translation in neurodevelopmental and neurodegenerative disease
2021
Overview
Neurons decentralize protein synthesis from the cell body to support the active metabolism of remote dendritic and axonal compartments. The neuronal RNA transport apparatus, composed of
cis
-acting RNA regulatory elements, neuronal transport granule proteins, and motor adaptor complexes, drives the long-distance RNA trafficking required for local protein synthesis. Over the past decade, advances in human genetics, subcellular biochemistry, and high-resolution imaging have implicated each member of the apparatus in several neurodegenerative diseases, establishing failed RNA transport and associated processes as a unifying pathomechanism. In this review, we deconstruct the RNA transport apparatus, exploring each constituent’s role in RNA localization and illuminating their unique contributions to neurodegeneration.
RNA localization is a defining and intricately regulated feature of neuronal physiology. Fernandopulle et al. review how altered RNA transport and local translation might inform understanding of neuronal disease.
Publisher
Nature Publishing Group US,Nature Publishing Group
Subject
