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Recent advances in modified poly (lactic acid) as tissue engineering materials

by Gürer, Eda Sönmez , Castañeda-Rodríguez, Samanta , Ribas-Aparicio, Rosa María , Sharifi‑Rad, Javad , Leyva‑Gómez, Gerardo , Del Prado‑Audelo, María Luisa , González-Torres, Maykel

in Acids / Applied Microbiology / Bacteria / Biocomposite / Biodegradability / Biodegradation / Biological products / Biological Techniques / Biomaterials / Biomedical Engineering and Bioengineering / Biomedical materials / Biopolymers / Biosynthesis / Biotechnology / Carbohydrates / Cell adhesion / Cell differentiation / Engineering / Environmental Engineering/Biotechnology / Enzymes / Fabrication / Fermentation / Glucose / Gram-positive bacteria / Metabolism / Microorganisms / Nanotechnology / Nucleic Acid Chemistry / Physicochemical properties / Poly (lactic acid) / Polylactic acid / Polymers / Regenerative medicine / Renewable resources / Review / Sustainable yield / Tissue Engineering

2023

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Recent advances in modified poly (lactic acid) as tissue engineering materials

by Gürer, Eda Sönmez , Castañeda-Rodríguez, Samanta , Ribas-Aparicio, Rosa María , Sharifi‑Rad, Javad , Leyva‑Gómez, Gerardo , Del Prado‑Audelo, María Luisa , González-Torres, Maykel

2023

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Recent advances in modified poly (lactic acid) as tissue engineering materials

by Gürer, Eda Sönmez , Castañeda-Rodríguez, Samanta , Ribas-Aparicio, Rosa María , Sharifi‑Rad, Javad , Leyva‑Gómez, Gerardo , Del Prado‑Audelo, María Luisa , González-Torres, Maykel

2023

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Journal Article

Recent advances in modified poly (lactic acid) as tissue engineering materials

Gürer, Eda Sönmez,

Castañeda-Rodríguez, Samanta,

Ribas-Aparicio, Rosa María,

Sharifi‑Rad, Javad,

Leyva‑Gómez, Gerardo,

Del Prado‑Audelo, María Luisa,

González-Torres, Maykel

2023

Overview

As an emerging science, tissue engineering and regenerative medicine focus on developing materials to replace, restore or improve organs or tissues and enhancing the cellular capacity to proliferate, migrate and differentiate into different cell types and specific tissues. Renewable resources have been used to develop new materials, resulting in attempts to produce various environmentally friendly biomaterials. Poly (lactic acid) (PLA) is a biopolymer known to be biodegradable and it is produced from the fermentation of carbohydrates. PLA can be combined with other polymers to produce new biomaterials with suitable physicochemical properties for tissue engineering applications. Here, the advances in modified PLA as tissue engineering materials are discussed in light of its drawbacks, such as biological inertness, low cell adhesion, and low degradation rate, and the efforts conducted to address these challenges toward the design of new enhanced alternative biomaterials.

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Publisher

BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC

Subject

Acids

/ Applied Microbiology

/ Biological products