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HDAC1 SUMOylation promotes Argonaute-directed transcriptional silencing in C. elegans
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HDAC1 SUMOylation promotes Argonaute-directed transcriptional silencing in C. elegans
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HDAC1 SUMOylation promotes Argonaute-directed transcriptional silencing in C. elegans
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Journal Article
HDAC1 SUMOylation promotes Argonaute-directed transcriptional silencing in C. elegans
2021
Overview
Eukaryotic cells use guided search to coordinately control dispersed genetic elements. Argonaute proteins and their small RNA cofactors engage nascent RNAs and chromatin-associated proteins to direct transcriptional silencing. The small ubiquitin-like modifier (SUMO) has been shown to promote the formation and maintenance of silent chromatin (called heterochromatin) in yeast, plants, and animals. Here, we show that Argonaute-directed transcriptional silencing in Caenorhabditis elegans requires SUMOylation of the type 1 histone deacetylase HDA-1. Our findings suggest how SUMOylation promotes the association of HDAC1 with chromatin remodeling factors and with a nuclear Argonaute to initiate de novo heterochromatin silencing.
Publisher
eLife Science Publications, Ltd,eLife Sciences Publications Ltd,eLife Sciences Publications, Ltd
Subject
/ Argonaute Proteins - genetics
/ Argonaute Proteins - metabolism
/ Caenorhabditis elegans - genetics
/ Chromatin Assembly and Disassembly
/ Enzymes
/ Genes
/ germline
/ Heterochromatin - metabolism
/ Histone Deacetylase 1 - genetics
/ Histone Deacetylase 1 - metabolism
/ Mutation
/ Proteins
/ RNA
/ Scientific equipment and supplies industry
/ Sensors
/ Worms
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