Asset Details
Do you wish to reserve the book?
Polycomb subunits Ezh1 and Ezh2 regulate the Merkel cell differentiation program in skin stem cells
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Polycomb subunits Ezh1 and Ezh2 regulate the Merkel cell differentiation program in skin stem cells
Do you wish to request the book?
Polycomb subunits Ezh1 and Ezh2 regulate the Merkel cell differentiation program in skin stem cells
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Polycomb subunits Ezh1 and Ezh2 regulate the Merkel cell differentiation program in skin stem cells
2013
Overview
While the Polycomb complex is known to regulate cell identity in ES cells, its role in controlling tissue‐specific stem cells is not well understood. Here we show that removal of Ezh1 and Ezh2, key Polycomb subunits, from mouse skin results in a marked change in fate determination in epidermal progenitor cells, leading to an increase in the number of lineage‐committed Merkel cells, a specialized subtype of skin cells involved in mechanotransduction. By dissecting the genetic mechanism, we showed that the Polycomb complex restricts differentiation of epidermal progenitor cells by repressing the transcription factor Sox2. Ablation of
Sox2
results in a dramatic loss of Merkel cells, indicating that Sox2 is a critical regulator of Merkel cell specification. We show that Sox2 directly activates
Atoh1
, the obligate regulator of Merkel cell differentiation. Concordantly, ablation of
Sox2
attenuated the
Ezh1/2
‐null phenotype, confirming the importance of Polycomb‐mediated repression of Sox2 in maintaining the epidermal progenitor cell state. Together, these findings define a novel regulatory network by which the Polycomb complex maintains the progenitor cell state and governs differentiation
in vivo
.
Ezh1/2‐mediated repression of the transcription factor Sox2 in epidermal progenitors extends the role of Polycomb proteins in controlling cellular identity beyond ES cells towards tissue‐specific stem cells.
Publisher
John Wiley & Sons, Ltd,Nature Publishing Group UK,Springer Nature B.V,Nature Publishing Group
Subject
/ Adult Stem Cells - metabolism
/ Animals
/ Basic Helix-Loop-Helix Transcription Factors - genetics
/ Basic Helix-Loop-Helix Transcription Factors - metabolism
/ Cell Differentiation - genetics
/ Cell Differentiation - physiology
/ EMBO07
/ EMBO09
/ Enhancer of Zeste Homolog 2 Protein
/ Female
/ Gene Expression Regulation, Developmental
/ LIM-Homeodomain Proteins - genetics
/ LIM-Homeodomain Proteins - metabolism
/ Mice
/ Polycomb
/ Polycomb Repressive Complex 2 - deficiency
/ Polycomb Repressive Complex 2 - genetics
/ Polycomb Repressive Complex 2 - metabolism
/ Skin
/ Sox2
/ SOXB1 Transcription Factors - deficiency
/ SOXB1 Transcription Factors - genetics
/ SOXB1 Transcription Factors - metabolism
