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Modulation of brain networks during MR-compatible transcranial direct current stimulation
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Modulation of brain networks during MR-compatible transcranial direct current stimulation
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Modulation of brain networks during MR-compatible transcranial direct current stimulation
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Journal Article
Modulation of brain networks during MR-compatible transcranial direct current stimulation
2022
Overview
Transcranial direct current stimulation (tDCS) can influence performance on behavioral tasks and improve symptoms of brain conditions. Yet, it remains unclear precisely how tDCS affects brain function and connectivity. Here, we measured changes in functional connectivity (FC) metrics in blood-oxygenation-level-dependent (BOLD) fMRI data acquired during MR-compatible tDCS in a whole-brain analysis with corrections for false discovery rate. Volunteers (n = 64) received active tDCS, sham tDCS, and rest (no stimulation), using one of three previously established electrode tDCS montages targeting left dorsolateral prefrontal cortex (DLPFC, n = 37), lateral temporoparietal area (LTA, n = 16), or superior temporal cortex (STC, n = 11). In brain networks where simulated E field was highest in each montage, connectivity with remote nodes decreased during active tDCS. During active DLPFC-tDCS, connectivity decreased between a fronto-parietal network and subgenual ACC, while during LTA-tDCS connectivity decreased between an auditory-somatomotor network and frontal operculum. Active DLPFC-tDCS was also associated with increased connectivity within an orbitofrontal network overlapping subgenual ACC. Irrespective of montage, FC metrics increased in sensorimotor and attention regions during both active and sham tDCS, which may reflect the cognitive-perceptual demands of tDCS. Taken together, these results indicate that tDCS may have both intended and unintended effects on ongoing brain activity, stressing the importance of including sham, stimulation-absent, and active comparators in basic science and clinical trials of tDCS.
Publisher
Elsevier Inc,Elsevier Limited,Elsevier
Subject
/ Brain
/ Electrical stimulation of the brain
/ ESB
/ Female
/ fMRI
/ Functional magnetic resonance imaging
/ Humans
/ Image Processing, Computer-Assisted
/ Magnetic Resonance Imaging - methods
/ Male
/ Neural Pathways - diagnostic imaging
/ Neural Pathways - physiology
/ Purpura
/ Transcranial direct current stimulation
