Asset Details
Do you wish to reserve the book?
Perivascular leukocyte clusters are essential for efficient activation of effector T cells in the skin
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Perivascular leukocyte clusters are essential for efficient activation of effector T cells in the skin
Do you wish to request the book?
Perivascular leukocyte clusters are essential for efficient activation of effector T cells in the skin
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Perivascular leukocyte clusters are essential for efficient activation of effector T cells in the skin
2014
Overview
How APCs encounter T cells in the periphery remains unclear. Kabashima and colleagues show that dendritic cells form macrophage-dependent clusters in dermal perivascular areas for efficient
in situ
proliferation and activation of T cells.
It remains largely unclear how antigen-presenting cells (APCs) encounter effector or memory T cells efficiently in the periphery. Here we used a mouse contact hypersensitivity (CHS) model to show that upon epicutaneous antigen challenge, dendritic cells (DCs) formed clusters with effector T cells in dermal perivascular areas to promote
in situ
proliferation and activation of skin T cells in a manner dependent on antigen and the integrin LFA-1. We found that DCs accumulated in perivascular areas and that DC clustering was abrogated by depletion of macrophages. Treatment with interleukin 1α (IL-1α) induced production of the chemokine CXCL2 by dermal macrophages, and DC clustering was suppressed by blockade of either the receptor for IL-1 (IL-1R) or the receptor for CXCL2 (CXCR2). Our findings suggest that the dermal leukocyte cluster is an essential structure for elicitating acquired cutaneous immunity.
Publisher
Nature Publishing Group US,Nature Publishing Group
Subject
/ 38/61
/ 38/77
/ Animals
/ CD4-Positive T-Lymphocytes - immunology
/ CD8-Positive T-Lymphocytes - immunology
/ Chemokine CXCL2 - biosynthesis
/ Dendritic Cells - immunology
/ Dermatitis, Contact - immunology
/ Female
/ Immunologic Memory - immunology
/ Interleukin-1alpha - pharmacology
/ Lymphocyte Activation - immunology
/ Lymphocyte Function-Associated Antigen-1 - immunology
/ Mice
/ Receptors, Interleukin-1 - antagonists & inhibitors
