Asset Details
Do you wish to reserve the book?
Essential Role of Linx/Islr2 in the Development of the Forebrain Anterior Commissure
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Essential Role of Linx/Islr2 in the Development of the Forebrain Anterior Commissure
Do you wish to request the book?
Essential Role of Linx/Islr2 in the Development of the Forebrain Anterior Commissure
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Essential Role of Linx/Islr2 in the Development of the Forebrain Anterior Commissure
2018
Overview
Linx is a member of the leucine-rich repeat and immunoglobulin family of membrane proteins which has critical roles in the development of the peripheral nervous system and forebrain connectivity. A previous study showed that Linx is expressed in projection neurons in the cortex and in cells that comprise the passage to the prethalamus that form the internal capsule, indicating the involvement of Linx in axon guidance and cell-cell communication. In this study, we found that Linx-deficient mice develop severe hydrocephalus and die perinatally by unknown mechanisms. Importantly, mice heterozygous for the
linx
gene exhibited defects in the development of the anterior commissure in addition to hydrocephalus, indicating haploinsufficiency of the
linx
gene in forebrain development. In N1E-115 neuroblastoma cells and primary cultured hippocampal neurons, Linx depletion led to impaired neurite extension and an increase in cell body size. Consistent with this, but of unknown significance, we found that Linx interacts with and upregulates the activity of Rho-kinase, a modulator of many cellular processes including cytoskeletal organization. These data suggest a role for Linx in the regulation of complex forebrain connectivity, and future identification of its extracellular ligand(s) will help clarify this function.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 14/35
/ 45/77
/ 64/60
/ 82/51
/ 82/58
/ Animals
/ Anterior Commissure, Brain - growth & development
/ Anterior Commissure, Brain - metabolism
/ Brain
/ Gene Expression Regulation, Developmental
/ Hippocampus - growth & development
/ Humanities and Social Sciences
/ Kinases
/ Leucine
/ Ligands
/ Limbic System - growth & development
/ Membrane Proteins - genetics
/ Mice
/ Nerve Tissue Proteins - genetics
/ Peripheral Nervous System - growth & development
/ Peripheral Nervous System - metabolism
/ Prosencephalon - growth & development
/ Proteins
/ Science
