Asset Details
Do you wish to reserve the book?
Mammalian prions and their wider relevance in neurodegenerative diseases
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Mammalian prions and their wider relevance in neurodegenerative diseases
Do you wish to request the book?
Mammalian prions and their wider relevance in neurodegenerative diseases
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Mammalian prions and their wider relevance in neurodegenerative diseases
2016
Overview
Prions are notorious protein-only infectious agents that cause invariably fatal brain diseases following silent incubation periods that can span a lifetime. These diseases can arise spontaneously, through infection or be inherited. Remarkably, prions are composed of self-propagating assemblies of a misfolded cellular protein that encode information, generate neurotoxicity and evolve and adapt
in vivo
. Although parallels have been drawn with Alzheimer's disease and other neurodegenerative conditions involving the deposition of assemblies of misfolded proteins in the brain, insights are now being provided into the usefulness and limitations of prion analogies and their aetiological and therapeutic relevance.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ 692/699
/ Amyloid beta-Peptides - chemistry
/ Amyloid beta-Peptides - classification
/ Amyloid beta-Peptides - metabolism
/ Animals
/ Humanities and Social Sciences
/ Humans
/ Kinetics
/ Mammals
/ Mutation
/ Neurodegenerative Diseases - genetics
/ Neurodegenerative Diseases - metabolism
/ Neurodegenerative Diseases - pathology
/ Neurodegenerative Diseases - therapy
/ Prions
/ Proteins
/ Science
/ Studies
