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Virus-Specific T-Cell Therapy for Viral Infections of the Central Nervous System: A Review
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Virus-Specific T-Cell Therapy for Viral Infections of the Central Nervous System: A Review
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Journal Article
Virus-Specific T-Cell Therapy for Viral Infections of the Central Nervous System: A Review
2023
Overview
Opportunistic viral infections of the central nervous system represent a significant cause of morbidity and mortality among an increasing number of immunocompromised patients. Since antiviral treatments are usually poorly effective, the prognosis generally relies on the ability to achieve timely immune reconstitution. Hence, strategies aimed at reinvigorating antiviral immune activity have recently emerged. Among these, virus-specific T-cells are increasingly perceived as a principled and valuable tool to treat opportunistic viral infections. Here we briefly discuss how to develop and select virus-specific T-cells, then review their main indications in central nervous system infections, including progressive multifocal leukoencephalopathy, CMV infection, and adenovirus infection. We also discuss their potential interest in the treatment of progressive multiple sclerosis, or EBV-associated central nervous system inflammatory disease. We finish with the key future milestones of this promising treatment strategy.
Publisher
MDPI AG,Multidisciplinary Digital Publishing Institute (MDPI),MDPI
Subject
/ Antigens
/ Antiviral Agents/therapeutic use
/ Blood
/ Cell- and Tissue-Based Therapy
/ Cells
/ Central Nervous System Diseases
/ Central Nervous System Diseases/therapy
/ HIV
/ Human immunodeficiency virus
/ Humans
/ Leukoencephalopathy, Progressive Multifocal
/ Patients
/ Progressive multifocal leukoencephalopathy
/ Proteins
/ Review
/ Sciences de la santé humaine
/ T cells
/ Testing
/ Virology
/ Viruses
