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Comprehensive elaboration of the cGAS-STING signaling axis in cancer development and immunotherapy

by Zhu, Tao , Yin, Jiye , Liu, Zhaoqian , Zhang, Wei , Zhuo, Wei , Zheng, Juyan , Zhou, Honghao , Yi, Yueneng , Mo, Junluan , Hu, Shuo

in Adaptive immunity / Agonists / AMP / Antitumor response / Binding sites / Biological response modifiers / Biomedical and Life Sciences / Biomedicine / Cancer / Cancer development / Cancer Research / Cancer therapies / Cancer treatment / Cell cycle / cGAS-STING / Chromosomes / Cyclic GMP / Cyclic guanosine monophosphate / Cytokines / Cytoplasm / Deoxyribonucleic acid / Development and progression / DNA / DNA damage / Drug therapy / Genes / Immune system / Immunotherapy / Infections / Inflammation / Innate immunity / Interferon / Kinases / Ligands / Mitochondrial DNA / Oncology / Oxidative stress / Pathogens / Phenotypes / Review / Senescence / Sensors / Signal transduction / STING agonists / Type I interferon

2020

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Comprehensive elaboration of the cGAS-STING signaling axis in cancer development and immunotherapy

by Zhu, Tao , Yin, Jiye , Liu, Zhaoqian , Zhang, Wei , Zhuo, Wei , Zheng, Juyan , Zhou, Honghao , Yi, Yueneng , Mo, Junluan , Hu, Shuo

2020

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Comprehensive elaboration of the cGAS-STING signaling axis in cancer development and immunotherapy

by Zhu, Tao , Yin, Jiye , Liu, Zhaoqian , Zhang, Wei , Zhuo, Wei , Zheng, Juyan , Zhou, Honghao , Yi, Yueneng , Mo, Junluan , Hu, Shuo

2020

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Journal Article

Comprehensive elaboration of the cGAS-STING signaling axis in cancer development and immunotherapy

Zhu, Tao,

Yin, Jiye,

Liu, Zhaoqian,

Zhang, Wei,

Zhuo, Wei,

Zheng, Juyan,

Zhou, Honghao,

Yi, Yueneng,

Mo, Junluan,

Hu, Shuo

2020

Overview

Cellular recognition of microbial DNA is an evolutionarily conserved mechanism by which the innate immune system detects pathogens. Cyclic GMP-AMP synthase (cGAS) and its downstream effector, stimulator of interferon genes (STING), are involved in mediating fundamental innate antimicrobial immunity by promoting the release of type I interferons (IFNs) and other inflammatory cytokines. Accumulating evidence suggests that the activation of the cGAS-STING axis is critical for antitumor immunity. The downstream cytokines regulated by cGAS-STING, especially type I IFNs, serve as bridges connecting innate immunity with adaptive immunity. Accordingly, a growing number of studies have focused on the synthesis and screening of STING pathway agonists. However, chronic STING activation may lead to a protumor phenotype in certain malignancies. Hence, the cGAS-STING signaling pathway must be orchestrated properly when STING agonists are used alone or in combination. In this review, we discuss the dichotomous roles of the cGAS-STING pathway in tumor development and the latest advances in the use of STING agonists.

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Publisher

BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC

Subject

/ AMP

/ Biological response modifiers

/ Biomedical and Life Sciences