Journal Article

A Wolbachia factor for male killing in lepidopteran insects

Shoji, Keisuke, Arimura, Shin-ichi, Matsuda-Imai, Noriko, Fujii, Takeshi, Hirota, Kanako, Kosako, Hidetaka, Nishino, Kohei, Kiuchi, Takashi, Muro, Tomohiro, Fukui, Takahiro, Takanashi, Hideki, Katsuma, Susumu

2022

Overview

Bacterial symbionts, such as Wolbachia species, can manipulate the sexual development and reproduction of their insect hosts. For example, Wolbachia infection induces male-specific death in the Asian corn borer Ostrinia furnacalis by targeting the host factor Masculinizer (Masc), an essential protein for masculinization and dosage compensation in lepidopteran insects. Here we identify a Wolbachia protein, designated Oscar, which interacts with Masc via its ankyrin repeats. Embryonic expression of Oscar inhibits Masc-induced masculinization and leads to male killing in two lepidopteran insects, O. furnacalis and the silkworm Bombyx mori . Our study identifies a mechanism by which Wolbachia induce male killing of host progeny. Bacterial symbionts, such as Wolbachia species, can manipulate the sexual development and reproduction of their insect hosts. Here, the authors identify a Wolbachia protein that interacts with a host masculinization factor and leads to male killing in lepidopteran insects.

• Publisher: Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
• Subject: 13 / 13/1 / 13/109 / 14 / 38 / 38/1 / 631/136/2086 / 631/326/41/547 / 631/326/41/88 / 631/80 / 82/1 / 82/58 / Animals / Ankyrins / Bacteria / Bombyx - genetics / Bombyx - metabolism / Bombyx mori / Cytoplasm / Dosage compensation / Dosage Compensation, Genetic / Embryos / Experiments / Genes / Humanities and Social Sciences / Infections / Insect Proteins - genetics / Insect Proteins - metabolism / Insects / Male / Males / Moths - microbiology / multidisciplinary / Ostrinia furnacalis / Progeny / Proteins / Reproduction (biology) / Science / Science (multidisciplinary) / Silkworms / Symbionts / Wolbachia / Wolbachia - metabolism