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Influence of adiponectin and inflammatory cytokines in fatty degenerative atrophic muscle
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Influence of adiponectin and inflammatory cytokines in fatty degenerative atrophic muscle
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Journal Article
Influence of adiponectin and inflammatory cytokines in fatty degenerative atrophic muscle
2022
Overview
Tendon rupture and nerve injury cause fatty infiltration of the skeletal muscle, and the adipokines secreted from the infiltrated adipocytes are known to contribute to chronic inflammation. Therefore, in this study, we evaluated the effects of the adipokines on chronic inflammation using a rat sciatic nerve-crushed injury model. In vitro and in vivo experiments showed that the expression of adiponectin was decreased (0.3-fold) and the expression of
Il6
(~ 3.8-fold) and
Tnf
(~ 6.2-fold) was increased in the nerve-crushed group compared to that in the control group. It was also observed that the administration of an adiponectin receptor agonist decreased the levels of
Il6
(0.38-fold) and
Tnf
(0.28-fold) and improved cellular viability (~ 1.9-fold) in vitro. Additionally, in the fatty infiltrated skeletal muscle, low adiponectin levels were found to be associated with chronic inflammation. Therefore, the local administration of adiponectin receptor agonists would prevent chronic inflammation.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 692/420
/ Agonists
/ Animals
/ Humanities and Social Sciences
/ Male
/ Muscle, Skeletal - drug effects
/ Muscle, Skeletal - metabolism
/ Muscle, Skeletal - pathology
/ Muscular Atrophy - metabolism
/ Muscular Atrophy - pathology
/ Rats
/ Receptors, Adiponectin - agonists
/ Receptors, Adiponectin - metabolism
/ Science
