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Journal Article
polymicrobial perspective of pulmonary infections exposes an enigmatic pathogen in cystic fibrosis patients
2008
Overview
Lung disease is the leading cause of morbidity and mortality in cystic fibrosis (CF) patients. A modest number of bacterial pathogens have been correlated with pulmonary function decline; however, microbiological and molecular evidence suggests that CF airway infection is polymicrobial. To obtain a more complete assessment of the microbial community composition and dynamics, we undertook a longitudinal study by using culture-independent and microbiological approaches. In the process, we demonstrated that within complex and dynamic communities, the Streptococcus milleri group (SMG) can establish chronic pulmonary infections and at the onset of 39% of acute pulmonary exacerbations, SMG is the numerically dominant pathogen. We report the comprehensive polymicrobial community dynamics of a CF lung infection in a clinically relevant context. If a given organism, such as Pseudomonas aeruginosa, becomes resistant to antibiotic therapy, an alternative treatment avenue may mediate the desired clinical response by effectively managing the composition of the microbial community.
Publisher
National Academy of Sciences,National Acad Sciences
Subject
/ Bacteria
/ Bacterial Infections - microbiology
/ Chronic obstructive pulmonary disease
/ Cystic Fibrosis - microbiology
/ Female
/ Humans
/ Lungs
/ Male
/ patients
/ Polymorphism, Restriction Fragment Length
/ Pseudomonas aeruginosa - drug effects
/ Pseudomonas aeruginosa - genetics
/ Pseudomonas aeruginosa - isolation & purification
/ Sputum
/ Streptococcus constellatus - drug effects
/ Streptococcus constellatus - genetics
