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Association of hepatitis B virus mutations in basal core promoter and precore regions with severity of liver disease : an investigation of 793 Chinese patients with mild and severe chronic hepatitis B and acute-on-chronic liver failure
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Association of hepatitis B virus mutations in basal core promoter and precore regions with severity of liver disease : an investigation of 793 Chinese patients with mild and severe chronic hepatitis B and acute-on-chronic liver failure
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Association of hepatitis B virus mutations in basal core promoter and precore regions with severity of liver disease : an investigation of 793 Chinese patients with mild and severe chronic hepatitis B and acute-on-chronic liver failure
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Journal Article
Association of hepatitis B virus mutations in basal core promoter and precore regions with severity of liver disease : an investigation of 793 Chinese patients with mild and severe chronic hepatitis B and acute-on-chronic liver failure
2011
Overview
Objective
To investigate the features of hepatitis B virus (HBV) basal core promoter/precore (BCP/PC) mutations and genotypes in a large number of mild/severe chronic hepatitis B (CHB-M/CHB-S), and acute-on-chronic liver failure (ACLF) patients and analyze the clinical implications of the virologic features.
Patients and methods
Sera of 793 (325 CHB-M, 170 CHB-S, and 298 ACLF) patients admitted to or who had visited Beijing 302 Hospital from January 2005 to December 2008 were collected and successfully amplified for the HBV BCP/PC and a 1225-bp-long S/Pol (nt 54–1278) gene regions. Biochemical and serological parameters and HBV DNA level were routinely performed. Viral DNA was extracted and subjected to a nested PCR. Genotypes/subgenotypes were determined based on complete genomic sequence or on analysis of the 1225-bp-long S/Pol-gene sequence. HBV genotyping was performed by direct PCR sequencing followed by molecular evolutionary analysis of the viral sequences. A
P
value of <0.05 (two-sided) was considered to be statistically significant.
Conclusions
Our findings suggest that CHB patients infected with BCP/PC mutant viruses are more susceptible to severe hepatitis and ACLF than those with the BCP/PC wild-type virus and that ACLF patients with PC mutant viruses have an increased risk of death. As such, the HBV PC mutation is a potential predictive indicator of ACLF outcome.
Publisher
Springer Japan,Springer,Springer Nature B.V
Subject
/ Acute-on-chronic liver failure
/ Adult
/ Alanine Transaminase - blood
/ Analysis
/ Asian Continental Ancestry Group
/ Basal core promoter mutation
/ Diseases
/ End Stage Liver Disease - blood
/ End Stage Liver Disease - virology
/ Female
/ Genotype
/ Hepatitis B e Antigens - blood
/ Hepatitis B virus - genetics
/ Hepatitis B, Chronic - blood
/ Hepatitis B, Chronic - pathology
/ Hepatitis B, Chronic - virology
/ Humans
/ Liver Failure, Acute - blood
/ Liver Failure, Acute - virology
/ Male
/ Medicine
/ Mutants
/ Mutation
/ Original —Liver, Pancreas, and Biliary Tract
/ Pancreas
/ Patients
/ Viruses
