Asset Details
Do you wish to reserve the book?
The genetics of early telencephalon patterning: some assembly required
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
The genetics of early telencephalon patterning: some assembly required
Do you wish to request the book?
The genetics of early telencephalon patterning: some assembly required
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
The genetics of early telencephalon patterning: some assembly required
2008
Overview
Key Points
The embryonic telencephalon starts off as a simple sheet of neuroepithelial cells. This neuroepithelium becomes patterned into distinct proliferative zones that ultimately generate the different neural cell types that make up the adult cerebral hemispheres.
Four broad regions can be defined in the early telencephalic neuroepithelium: a cortical area that generates primarily glutamatergic neurons, a dorso-medial area that induces the hippocampus and produces the choroid plexus, a ventro-medial area that generates subtypes of GABA (γ-aminobutyric acid)-ergic interneurons, and a caudo-lateral area that generates different subtypes of interneurons and inhibitory projection neurons.
The development of the ventral areas of the telencephalon is established by the attenuation of dorsalizing signals by sonic hedgehog and the activation of ventral patterning by fibroblast growth factors.
Forkhead box G1 interacts with different factors and is required for both dorsal and ventral patterning.
Establishment of the pallial–subpallial boundary involves antagonistic interactions between key transcription factors, including NKX2.1, paired box 6, GSH2 and TLX.
A dorsal midline organizer helps to establish pallial subdivisions.
The genetic interactions that pattern the embryonic telencephalon are highly complex. Fishell and Hébert bring clarity to these events by describing the key genetic interactions that underlie the patterning of the early telencephalon into distinct proliferative zones.
The immense range of human behaviours is rooted in the complex neural networks of the cerebrum. The creation of these networks depends on the precise integration of specific neuronal subtypes that are born in different regions of the telencephalon. Here, using the mouse as a model system, we review how these proliferative zones are established. Moreover, we discuss how these regions can be traced back in development to the function of a few key genes, including those that encode fibroblast growth factors (FGFs), sonic hedgehog (SHH), bone morphogenetic proteins (BMPs), forkhead box G1 (FOXG1), paired box 6 (PAX6) and LIM homeobox protein 2 (LHX2), that pattern the early telencephalon.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ Animals
/ Biological and medical sciences
/ Biomedical and Life Sciences
/ Body Patterning - physiology
/ Bone Morphogenetic Proteins - genetics
/ Development. Senescence. Regeneration. Transplantation
/ Embryology: invertebrates and vertebrates. Teratology
/ Fibroblast Growth Factors - genetics
/ Fundamental and applied biological sciences. Psychology
/ Genes
/ Hedgehog Proteins - genetics
/ Humans
/ Mice
/ Organogenesis. Fetal development
/ Organogenesis. Physiological fonctions
/ Telencephalon - growth & development
