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ICP10PK inhibits calpain-dependent release of apoptosis-inducing factor and programmed cell death in response to the toxin MPP
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ICP10PK inhibits calpain-dependent release of apoptosis-inducing factor and programmed cell death in response to the toxin MPP
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Journal Article
ICP10PK inhibits calpain-dependent release of apoptosis-inducing factor and programmed cell death in response to the toxin MPP
2008
Overview
Apoptosis is a widely accepted component of the pathogenesis of Parkinson's disease (PD), a debilitating neurodegenerative disorder characterized by loss of dopaminergic neurons in the substantia nigra. However, additional death programs were implicated, and current understanding of the cycle of intracellular events that leads to the demise of these neuronJis limited. Gene therapy strategies were proposed to inhibit apoptosis, but they have met with relatively limited success. Here we report that the antiapoptotic herpes simplex virus type 2 gene
ICP10PK
protects neuronally differentiated PC12 cells from death caused by 1-methyl-4-phenylpyridinium (
in vitro
PD model) through inhibition of calpain I activation and the resulting inhibition of Bax translocation to the mitochondria, apoptosis-inducing factor release and caspase-3 activation. Neuroprotection is through ICP10PK-mediated activation of the PI3-K/Akt survival pathway and upregulation/stabilization of the antiapoptotic protein Bcl-2 and the cytoprotective chaperone heat-shock protein 70.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
1-Methyl-4-phenylpyridinium - pharmacology
/ 1-Phosphatidylinositol 3-kinase
/ Animals
/ Apoptosis Inducing Factor - metabolism
/ bcl-2-Associated X Protein - metabolism
/ Biomedical and Life Sciences
/ Calpain
/ Calpain - antagonists & inhibitors
/ HSP70 Heat-Shock Proteins - metabolism
/ MPP
/ Parkinson Disease - genetics
/ Phosphatidylinositol 3-Kinases - metabolism
/ Protein Serine-Threonine Kinases - genetics
/ Proto-Oncogene Proteins c-bcl-2 - metabolism
/ Rats
/ Ribonucleotide Reductases - genetics
/ Toxins, Biological - pharmacology
/ Viruses
