Asset Details

MbrlCatalogueTitleDetail

Do you wish to reserve the book?

Common variants in ACYP2 influence susceptibility to cisplatin-induced hearing loss

by Zhang, Hui , Chintagumpala, Murali , Gajjar, Amar , Hassall, Tim , Huang, Jie , Gururangan, Sri , Fisher, Michael , Yamashita, Tetsuji , Lim, Joshua Yew-Suang , Onar-Thomas, Arzu , Broniscer, Alberto , Bass, Johnnie K , Robinson, Giles W , Cohn, Richard , Zuo, Jian , Yang, Jun J , Stewart, Clinton F , Bartels, Ute , Xu, Heng , Teitz, Tal

in 45 / 45/43 / 631/208/205/2138 / 692/308/575 / 692/699/67/1059/99 / Acid Anhydride Hydrolases - genetics / Acylphosphatase / Age / Agriculture / Animal Genetics and Genomics / Antineoplastic Agents - adverse effects / Biomedicine / Brain cancer / Brain Neoplasms - drug therapy / Brain Neoplasms - enzymology / Brain Neoplasms - genetics / Brain research / Brain tumors / Cancer Research / Child, Preschool / Cisplatin / Cisplatin - adverse effects / Clinical Trials as Topic / Complications and side effects / Confidence intervals / Female / Free radicals / Gene Function / Genealogy / Genes / Genetic aspects / Genetic diversity / Genetic Predisposition to Disease / Genome-Wide Association Study - methods / Genomes / Genotype & phenotype / Hearing loss / Hearing Loss - chemically induced / Hearing Loss - enzymology / Hearing Loss - genetics / Human Genetics / Humans / Infant / letter / Male / Ototoxicity / Patients / Polymorphism, Single Nucleotide / Risk factors / Single nucleotide polymorphisms / Studies / Tumors

2015

Yes Please

Hey, we have placed the reservation for you!

By the way, why not check out events that you can attend while you pick your title.

Oops! Something went wrong.

Looks like we were not able to place the reservation. Kindly try again later.

Are you sure you want to remove the book from the shelf?

Common variants in ACYP2 influence susceptibility to cisplatin-induced hearing loss

2015

Confirm

Do you wish to request the book?

Common variants in ACYP2 influence susceptibility to cisplatin-induced hearing loss

2015

Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy

How would you like to get it?

Submit

We have requested the book for you!

Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.

Oops! Something went wrong.

Looks like we were not able to place your request. Kindly try again later.

Journal Article

Common variants in ACYP2 influence susceptibility to cisplatin-induced hearing loss

Zhang, Hui,

Chintagumpala, Murali,

Gajjar, Amar,

Hassall, Tim,

Huang, Jie,

Gururangan, Sri,

Fisher, Michael,

Yamashita, Tetsuji,

Lim, Joshua Yew-Suang,

Onar-Thomas, Arzu,

Broniscer, Alberto,

Bass, Johnnie K,

Robinson, Giles W,

Cohn, Richard,

Zuo, Jian,

Yang, Jun J,

Stewart, Clinton F,

Bartels, Ute,

Xu, Heng,

Teitz, Tal

2015

Overview

Jun Yang, Clinton Stewart and colleagues report the results of a genome-wide association study of cisplatin-induced ototoxicity among children undergoing treatment for brain tumors. They identify common variants in ACYP2 strongly associated with cisplatin-induced hearing loss and ototoxicity severity. Taking a genome-wide association study approach, we identified inherited genetic variations in ACYP2 associated with cisplatin-related ototoxicity (rs1872328: P = 3.9 × 10 −8 , hazard ratio = 4.5) in 238 children with newly diagnosed brain tumors, with independent replication in 68 similarly treated children. The ACYP2 risk variant strongly predisposed these patients to precipitous hearing loss and was related to ototoxicity severity. These results point to new biology underlying the ototoxic effects of platinum agents.

Share this book

Add to My Shelf

Publisher

Nature Publishing Group US,Nature Publishing Group

Subject

/ 45/43

/ 631/208/205/2138

/ 692/308/575

/ 692/699/67/1059/99

/ Acid Anhydride Hydrolases - genetics

/ Acylphosphatase

/ Age